Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9JMK0 | - |
- |
Mus musculus | Q9WVK5 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
B4GalT5 | - |
Mus musculus |
B4GalT6 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | generation of conditional knockout B4galt5 and B4galt6 double KO mice in the central nervous system. Lactosylceramide synthase activity and major brain gangliosides are completely absent in brain homogenates from the double KO mice, although Lactosylceramide synthase activity is about half its normal level in B4galt5 coditional KO mice and B4galt6 KO mice. The double KO mice are born normally but show growth retardation and motor deficits at 2 weeks and die by 4 weeks of age. Myelin-associated proteins are rarely found localized in axons in the cerebral cortex, and axonal and myelin formation are remarkably impaired in the spinal cords of the double KO mice. Neuronal cells, differentiated from isolated neurospheres, show impairments in neurite outgrowth and branch formation. The neurons are immature and perineuronal nets are poorly formed in double KO cerebral cortices | Mus musculus |