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Literature summary for 2.4.1.27 extracted from

  • Lariviere, L.; Sommer, N.; Morera, S.
    Structural evidence of a passive base-flipping mechanism for AGT, an unusual GT-B glycosyltransferase (2005), J. Mol. Biol., 352, 139-150.
    View publication on PubMed
Search for more literature for 2.4.1.27

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Tequatrovirus T4 the AGT with GT-B glycosyltransferase fold is responsible for DNA base flipping and substrate recognition, mechanism, overview ?
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 ?
UDP-D-glucose + 5-hydroxymethyl cytosine Tequatrovirus T4 5-hydroxymethyl cytosine residues of duplex DNA UDP + 5-hydroxymethyl cytosine beta-D-glucoside
-
 ?

Organism

Organism UniProt Comment Textmining
Tequatrovirus T4
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 from Escherichia coli
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Reaction

Reaction Comment Organism Reaction ID
UDP-alpha-D-glucose + 5-hydroxymethylcytosine containing DNA = UDP + beta-D-glucosyl-5-hydroxymethylcytosine containing DNA catalytic mechanism, substrate binding structures, overview Tequatrovirus T4
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the AGT with GT-B glycosyltransferase fold is responsible for DNA base flipping and substrate recognition, mechanism, overview Tequatrovirus T4 ?
-
 ?
additional information the alpha-linkage forming enzyme AGT is also able to adopt the fold of a GT-B glycosyltransferase keeping the sugar donor binding mechanism typical for GT-B glycosyltransferases, but showing a unique sugar acceptor binding mode, both substrates are bound to the C-terminal domain, detailed substrate binding structures, catalytic mechanism of both enzyme types, overview Tequatrovirus T4 ?
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 ?
UDP-D-glucose + 5-hydroxymethyl cytosine 5-hydroxymethyl cytosine residues of duplex DNA Tequatrovirus T4 UDP + 5-hydroxymethyl cytosine beta-D-glucoside
-
 ?

Subunits

Subunits Comment Organism
More structural analysis of domain folding, substrate binding, catalytic mechanism, and base flipping mechanism, overview Tequatrovirus T4

Synonyms

Synonyms Comment Organism
BGT
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 Tequatrovirus T4
GT-B glycosyltransferase
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 Tequatrovirus T4
More the enzyme belongs to the GT-B glycosyltransferase family Tequatrovirus T4