Literature summary for 2.4.1.255 extracted from

Cao, B.; Duan, M.; Xing, Y.; Liu, C.; Yang, F.; Li, Y.; Yang, T.; Wei, Y.; Gao, Q.; Jiang, J.
O-GlcNAc transferase activates stem-like cell potential in hepatocarcinoma through O-GlcNAcylation of eukaryotic initiation factor 4E (2019), J. Cell. Mol. Med., 23, 2384-2398 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15294	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatoma cell	the level of total O-GlcNAcylation or O-GlcNAc transferase protein is increased in hepatocellular carcinoma	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
O-GlcNAc transferase	-	Homo sapiens
OGT	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	dysregulation of O-GlcNAcylation in response to high glucose or O-GlcNAc transferase expression has been implicated in metabolic diseases and cancer. Knockdown of O-GlcNAc transferase suppresses cell growth and stem-like cell potential of hepatoma cell	Homo sapiens
physiological function	O-GlcNAcylation catalysed by O-GlcNAc transferase is a reversible posttranslational modification. O-GlcNAcylation participates in transcription, epigenetic regulation, and intracellular signalling	Homo sapiens
physiological function	the enzyme activates stem-like cell potential in hepatocarcinoma through O-GlcNAcylation of eukaryotic initiation factor 4E	Homo sapiens

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Release 2023.1 (January 2023)