Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15294 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatoma cell | the level of total O-GlcNAcylation or O-GlcNAc transferase protein is increased in hepatocellular carcinoma | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
O-GlcNAc transferase | - |
Homo sapiens |
OGT | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | dysregulation of O-GlcNAcylation in response to high glucose or O-GlcNAc transferase expression has been implicated in metabolic diseases and cancer. Knockdown of O-GlcNAc transferase suppresses cell growth and stem-like cell potential of hepatoma cell | Homo sapiens |
physiological function | O-GlcNAcylation catalysed by O-GlcNAc transferase is a reversible posttranslational modification. O-GlcNAcylation participates in transcription, epigenetic regulation, and intracellular signalling | Homo sapiens |
physiological function | the enzyme activates stem-like cell potential in hepatocarcinoma through O-GlcNAcylation of eukaryotic initiation factor 4E | Homo sapiens |