Literature summary for 2.4.1.255 extracted from

Levine, Z.G.; Fan, C.; Melicher, M.S.; Orman, M.; Benjamin, T.; Walker, S.
O-GlcNAc transferase recognizes protein substrates using an asparagine ladder in the tetratricopeptide repeat (TPR) superhelix (2018), J. Am. Chem. Soc., 140, 3510-3513 .

Search for more literature for 2.4.1.255

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15294	UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 110 kDa subunit	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-serine	the enzyme recognizes the majority of its substrates by binding them to the asparagine ladder within the lumen of superhelical tetratricopeptide repeat (TPR) domain of the enzyme	Homo sapiens	UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine	-	?
UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-threonine	the enzyme recognizes the majority of its substrates by binding them to the asparagine ladder within the lumen of superhelical tetratricopeptide repeat (TPR) domain of the enzyme	Homo sapiens	UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine	-	?

Synonyms

Synonyms	Comment	Organism
O-GlcNAc transferase	-	Homo sapiens
OGT	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	the enzyme uniquely responsible for transferring N-acetylglucosamine to over a thousand nuclear and cytoplasmic proteins	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)