Literature summary for 2.4.1.255 extracted from

Ghirardello, M.; Perrone, D.; Chinaglia, N.; Sadaba, D.; Delso, I.; Tejero, T.; Marchesi, E.; Fogagnolo, M.; Rafie, K.; van Aalten, D.M.F.; Merino, P.
UDP-GlcNAc analogues as inhibitors of O-GlcNAc transferase (OGT) spectroscopic, computational, and biological studies (2018), Chemistry, 24, 7264-7272 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
5'-O-(hydroxy[3-[(2R,3R)-3-hydroxypyrrolidin-2-yl]propyl]phosphoryl)uridine	-	Homo sapiens
5'-O-(hydroxy[3-[(2R,3R,4S,5R)-3,4,5-trihydroxypyrrolidin-2-yl]propyl]phosphoryl)uridine	-	Homo sapiens
5'-O-(hydroxy[3-[(2R,3R,4S,5R)-3,4,5-tris(benzyloxy)pyrrolidin-2-yl]propyl]phosphoryl)uridine	-	Homo sapiens
5'-O-[[(2-(N-acetyl-akoga-D-glucosaminopyranosyl)-2,3-dihydro-1H-1,2,3-triazol-4-yl)methyl](hydroxy)phosphoryl]uridine	-	Homo sapiens
5'-O-[[(2-(N-acetyl-beta-D-glucosaminopyranosyl)-2,3-dihydro-1H-1,2,3-triazol-4-yl)methyl](hydroxy)phosphoryl]uridine	-	Homo sapiens
5'-O-[[(2-alpha-D-glucopyranosyl-2,3-dihydro-1H-1,2,3-triazol-4-yl)methyl](hydroxy)phosphoryl]uridine	-	Homo sapiens
5'-O-[[(2-beta-D-glucopyranosyl-2,3-dihydro-1H-1,2,3-triazol-4-yl)methyl](hydroxy)phosphoryl]uridine	-	Homo sapiens
5'-O-[[3-(alpha-D-glucopyranosyl)propyl](hydroxy)phosphoryl]uridine	-	Homo sapiens
5'-O-[[3-(N-acetyl-alpha-D-glucosaminopyranosyl)propyl](hydroxy)phosphoryl]uridine	-	Homo sapiens
5'-O-[[3-[(2R,3R)-3-(benzyloxy)pyrrolidin-2-yl]propyl](hydroxy)phosphoryl]uridine	-	Homo sapiens
5'-O-[[3-[(2R,3S,4S)-3,4-bis(benzyloxy)pyrrolidin-2-yl]propyl](hydroxy)phosphoryl]uridine	-	Homo sapiens
5'-O-[[3-[(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]propyl](hydroxy)phosphoryl]uridine	-	Homo sapiens
5'-O-[[3-[(2S,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]propyl](hydroxy)phosphoryl]uridine	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15294	-	-

Synonyms

Synonyms	Comment	Organism
O-GlcNAc transferase	-	Homo sapiens
OGT	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.102	-	pH and temperature not specified in the publication	Homo sapiens	5'-O-(hydroxy[3-[(2R,3R,4S,5R)-3,4,5-tris(benzyloxy)pyrrolidin-2-yl]propyl]phosphoryl)uridine
0.231	-	pH and temperature not specified in the publication	Homo sapiens	5'-O-[[(2-(N-acetyl-beta-D-glucosaminopyranosyl)-2,3-dihydro-1H-1,2,3-triazol-4-yl)methyl](hydroxy)phosphoryl]uridine
0.589	-	pH and temperature not specified in the publication	Homo sapiens	5'-O-[[(2-(N-acetyl-akoga-D-glucosaminopyranosyl)-2,3-dihydro-1H-1,2,3-triazol-4-yl)methyl](hydroxy)phosphoryl]uridine
0.718	-	pH and temperature not specified in the publication	Homo sapiens	5'-O-[[3-[(2R,3R)-3-(benzyloxy)pyrrolidin-2-yl]propyl](hydroxy)phosphoryl]uridine
1.048	-	pH and temperature not specified in the publication	Homo sapiens	5'-O-[[(2-alpha-D-glucopyranosyl-2,3-dihydro-1H-1,2,3-triazol-4-yl)methyl](hydroxy)phosphoryl]uridine
1.14	-	pH and temperature not specified in the publication	Homo sapiens	5'-O-[[3-[(2R,3S,4S)-3,4-bis(benzyloxy)pyrrolidin-2-yl]propyl](hydroxy)phosphoryl]uridine
1.439	-	pH and temperature not specified in the publication	Homo sapiens	5'-O-[[(2-beta-D-glucopyranosyl-2,3-dihydro-1H-1,2,3-triazol-4-yl)methyl](hydroxy)phosphoryl]uridine
1.804	-	pH and temperature not specified in the publication	Homo sapiens	5'-O-[[3-[(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]propyl](hydroxy)phosphoryl]uridine
1.814	-	pH and temperature not specified in the publication	Homo sapiens	5'-O-(hydroxy[3-[(2R,3R,4S,5R)-3,4,5-trihydroxypyrrolidin-2-yl]propyl]phosphoryl)uridine
2.218	-	pH and temperature not specified in the publication	Homo sapiens	5'-O-(hydroxy[3-[(2R,3R)-3-hydroxypyrrolidin-2-yl]propyl]phosphoryl)uridine
4.769	-	pH and temperature not specified in the publication	Homo sapiens	5'-O-[[3-(N-acetyl-alpha-D-glucosaminopyranosyl)propyl](hydroxy)phosphoryl]uridine
5.452	-	pH and temperature not specified in the publication	Homo sapiens	5'-O-[[3-[(2S,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]propyl](hydroxy)phosphoryl]uridine

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Release 2023.1 (January 2023)