Literature summary for 2.4.1.255 extracted from

She, N.; Zhao, Y.; Hao, J.; Xie, S.; Wang, C.
Uridine diphosphate release mechanism in O-N-acetylglucosamine (O-GlcNAc) transferase catalysis (2019), Biochim. Biophys. Acta Gen. Subj., 1863, 609-622 .

Search for more literature for 2.4.1.255

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-serine	Homo sapiens	essential enzyme that catalyzes the covalent bonding of N-acetylglucosamine to the hydroxyl group of a serine or threonine in the target protein. It plays an important role in many important cellular physiological catalytic reactions	UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine	-	?
UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-threonine	Homo sapiens	essential enzyme that catalyzes the covalent bonding of N-acetylglucosamine to the hydroxyl group of a serine or threonine in the target protein. It plays an important role in many important cellular physiological catalytic reactions	UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15294	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-serine	essential enzyme that catalyzes the covalent bonding of N-acetylglucosamine to the hydroxyl group of a serine or threonine in the target protein. It plays an important role in many important cellular physiological catalytic reactions	Homo sapiens	UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine	-	?
UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-serine	Lys634, Asn838, Gln839, Lys842, His901, and Asp925 play an important role in stabilizing UDP at the active site of the enzyme via hydrogen bonds and pi-pi interactions. The binding free energy of the UDP-enzyme complex is mainly constituted by electrostatic interactions and side chain effects. The uridine diphosphate release mechanism is studied	Homo sapiens	UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine	-	?
UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-threonine	essential enzyme that catalyzes the covalent bonding of N-acetylglucosamine to the hydroxyl group of a serine or threonine in the target protein. It plays an important role in many important cellular physiological catalytic reactions	Homo sapiens	UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine	-	?
UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-threonine	Lys634, Asn838, Gln839, Lys842, His901, and Asp925 play an important role in stabilizing UDP at the active site of the enzyme via hydrogen bonds and pi-pi interactions. The binding free energy of the UDP-enzyme complex is mainly constituted by electrostatic interactions and side chain effects. The uridine diphosphate release mechanism is studied	Homo sapiens	UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine	-	?

Synonyms

Synonyms	Comment	Organism
O-GlcNAc transferase	-	Homo sapiens
O-linked N-acetylglucosamine transferase	-	Homo sapiens
O-N-acetylglucosamine (O-GlcNAc) transferase	-	Homo sapiens
OGT	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	O-N-acetylglucosamine (O-GlcNAc) transferase is the only one enzyme responsible for O-GlcNAc glycosylation in more than 1000 proteins and plays an extremely significant role in biochemical processes	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)