Organism | UniProt | Comment | Textmining |
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Homo sapiens | - |
- |
- |
General Information | Comment | Organism |
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physiological function | O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), interact with the Agamma-globin promoter at the -566 GATA repressor site. O-GlcNAcylation is a mechanism of gamma-globin gene regulation, mediated by modulating the assembly of the GATA-1/FOG-1/Mi2beta repressor complex at the -566 GATA motif within the promoter. Inhibition of OGA by thiamet-G leads to increased occupancy of OGT, OGA and Mi2beta at the Agamma-globin promoter and decreased gamma-globin transcription level. Both OGT and OGA can interact with Mi2beta, GATA-1 and FOG-1, and Mi2beta is OGlcNAcylated | Homo sapiens |