Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hippocampus | - |
Rattus norvegicus | - |
neuron | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
mitochondrial motor-adaptor protein milton + UDP-GlcNAc | - |
Rattus norvegicus | ? + UDP | mitochondrial motor-adaptor protein Milton is a required substrate for OGT to arrest mitochondrial motility by mapping and mutating the key O-GlcNAcylated serine residues | ? |
General Information | Comment | Organism |
---|---|---|
physiological function | increased extracellular glucose decreases mitochondrial motility in hippocampal axons, and OGT overexpression reduces axonal mitochondrial motility and density. The mitochondrial motor-adaptor protein Milton is a required substrate for OGT to arrest mitochondrial motility by mapping and mutating the key O-GlcNAcylated serine residues | Rattus norvegicus |