Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli Tuner cells | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0022 | - |
UDP-GlcNAc | using calcium/calmodulin-dependent kinase IV as cosubstrate, at 37°C, pH not specified in the publication | Homo sapiens | |
0.0047 | - |
UDP-GlcNAc | using CARM1 protein as cosubstrate, at 37°C, pH not specified in the publication | Homo sapiens | |
0.0058 | - |
UDP-GlcNAc | using Nup62 protein as cosubstrate, at 37°C, pH not specified in the publication | Homo sapiens | |
0.007 | - |
UDP-GlcNAc | using TAB1 protein as cosubstrate, at 37°C, pH not specified in the publication | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15294 | - |
- |
Purification (Comment) | Organism |
---|---|
HisTrap nickel column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | no activity with Tau protein | Homo sapiens | ? | - |
? | |
UDP-GlcNAc + calcium/calmodulin-dependent kinase IV | - |
Homo sapiens | UDP + N-acetyl-D-glucosaminyl-[calcium/calmodulin-dependent kinase IV] | - |
? | |
UDP-GlcNAc + CARM1 protein | - |
Homo sapiens | UDP + N-acetyl-D-glucosaminyl-[CARM1 protein] | - |
? | |
UDP-GlcNAc + Nup62 protein | - |
Homo sapiens | UDP + N-acetyl-D-glucosaminyl-[Nup62 protein] | - |
? | |
UDP-GlcNAc + TAB1 protein | - |
Homo sapiens | UDP + N-acetyl-D-glucosaminyl-[TAB1 protein] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
O-GlcNAc transferase | - |
Homo sapiens |
OGT | - |
Homo sapiens |
uridine diphosphate-N-acetyl-D-glucosamine:polypeptidyltransferase | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000073 | - |
UDP-GlcNAc | using CARM1 as cosubstrate, at 37°C, pH not specified in the publication | Homo sapiens | |
0.000077 | - |
UDP-GlcNAc | using calcium/calmodulin-dependent kinase IV as cosubstrate, at 37°C, pH not specified in the publication | Homo sapiens | |
0.00057 | - |
UDP-GlcNAc | using TAB1 as cosubstrate, at 37°C, pH not specified in the publication | Homo sapiens | |
0.00093 | - |
UDP-GlcNAc | using Nup62 as cosubstrate, at 37°C, pH not specified in the publication | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme probably plays a senior role in determining O-linked N-acetylglucosamine levels | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.016 | - |
UDP-GlcNAc | using CARM1 protein as cosubstrate, at 37°C, pH not specified in the publication | Homo sapiens | |
0.035 | - |
UDP-GlcNAc | using calcium/calmodulin-dependent kinase IV as cosubstrate, at 37°C, pH not specified in the publication | Homo sapiens | |
0.08 | - |
UDP-GlcNAc | using TAB1 protein as cosubstrate, at 37°C, pH not specified in the publication | Homo sapiens | |
0.16 | - |
UDP-GlcNAc | using Nup62 protein as cosubstrate, at 37°C, pH not specified in the publication | Homo sapiens |