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Literature summary for 2.4.1.242 extracted from
- Unusual sugar nucleotide recognition elements of mesophilic vs. thermophilic glycogen synthases (2005), Biopolymers, 79, 106-113.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adenosine | - |
Pyrococcus furiosus |  |
| ADP | - |
Pyrococcus furiosus | |
| AMP | - |
Pyrococcus furiosus | |
| D-glucose | - |
Pyrococcus furiosus | |
| D-glucose 1-phosphate | - |
Pyrococcus furiosus | |
| UDP | - |
Pyrococcus furiosus | |
| UDP-galactose | competitive | Pyrococcus furiosus | |
| UMP | - |
Pyrococcus furiosus | |
| uridine | - |
Pyrococcus furiosus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 3.9 | - |
GDP-glucose | - |
Pyrococcus furiosus | |
| 4 | - |
dTDP-glucose | - |
Pyrococcus furiosus | |
| 4.1 | - |
UDP-glucose | - |
Pyrococcus furiosus | |
| 4.1 | - |
ADP-glucose | - |
Pyrococcus furiosus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pyrococcus furiosus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP-glucose + (1,4-alpha-D-glucosyl)n | - |
Pyrococcus furiosus | ADP + (1,4-alpha-D-glucosyl)n+1 | - |
? | |
| dTDP-glucose + (1,4-alpha-D-glucosyl)n | - |
Pyrococcus furiosus | dTDP + (1,4-alpha-D-glucosyl)n+1 | - |
? | |
| GDP-glucose + (1,4-alpha-D-glucosyl)n | - |
Pyrococcus furiosus | GDP + (1,4-alpha-D-glucosyl)n+1 | - |
? | |
| additional information | the enzyme gains most of its substrate affinity through electrostatic interactions between the enzyme and the alpha-phosphate. No activity with UDP-galactose, no phosphorylase activity | Pyrococcus furiosus | ? | - |
? | |
| UDP-glucose + (1,4-alpha-D-glucosyl)n | - |
Pyrococcus furiosus | UDP + (1,4-alpha-D-glucosyl)n+1 | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 3.7 | - |
AMP | - |
Pyrococcus furiosus | |
| 5.4 | - |
ADP | - |
Pyrococcus furiosus | |
| 5.4 | - |
UDP | - |
Pyrococcus furiosus | |
| 6.5 | - |
UMP | - |
Pyrococcus furiosus | |
| 17 | - |
UDP-galactose | - |
Pyrococcus furiosus | |
| 90 | - |
uridine | - |
Pyrococcus furiosus | |
| 120 | - |
D-glucose 1-phosphate | - |
Pyrococcus furiosus | |
| 290 | - |
D-glucose | - |
Pyrococcus furiosus | |
| 580 | - |
adenosine | - |
Pyrococcus furiosus | |
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Release 2023.1 (January 2023)
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