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Literature summary for 2.4.1.232 extracted from

  • Jungmann, J.; Munro, S.
    Multi-protein complexes in the cis Golgi of Saccharomyces cerevisiae with alpha-1,6-mannosyltransferase activity (1998), EMBO J., 17, 423-434.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus Mnn9p, primarily localized to the cis Golgi, type II transmembrane protein Saccharomyces cerevisiae 5794
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae two distinct Mnn9p-containing multi-protein complexes are responsible for the synthesis and initial branching of the long alpha-1,6-linked backbone of the hypermannose structure attached to many yeast glycoproteins, the long alpha-1,6-linked backbone is attached to an initial alpha-1,6-mannose residue transferred to the core structure by Och1p ?
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-mannose + alpha-1,6-D-mannobiose two distinct Mnn9p-containing multi-protein complexes add multiple mannosyl residues forming a series of poly-mannose structures in vitro, no substrate of Och1p Saccharomyces cerevisiae ? formation of a series of poly-mannose structures, which contain mainly alpha-1,6- and some additional alpha-1,2-linked mannoses ?
GDP-mannose + oligosaccharide acceptor Mnn9p is associated in two distinct multi-protein complexes, both having alpha-1,6-mannosyltransferase activity, they add multiple mannosyl residues forming hypermannose structures, Och1p adds the initiating alpha-1,6-mannose residue to an N-linked Man8GlcNAc2 structure, the Mnn9p-containing protein complexes add further alpha-1,6-mannose residues synthesizing the backbone of the outer chain of N-linked glycans Saccharomyces cerevisiae GDP + alpha-mannosyl-1,6-oligosaccharide
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additional information Mnn9p, no acceptor: alpha-1,2-mannobiose Saccharomyces cerevisiae ?
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additional information two distinct Mnn9p-containing multi-protein complexes are responsible for the synthesis and initial branching of the long alpha-1,6-linked backbone of the hypermannose structure attached to many yeast glycoproteins, the long alpha-1,6-linked backbone is attached to an initial alpha-1,6-mannose residue transferred to the core structure by Och1p Saccharomyces cerevisiae ?
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?

Synonyms

Synonyms Comment Organism
Mnn9p Saccharomyces cerevisiae, part of two elongating alpha-1,6-mannosyltransferase complexes Saccharomyces cerevisiae
Och1p Saccharomyces cerevisiae, initiating alpha-1,6-mannosyltransferase Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
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assay at Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
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assay at Saccharomyces cerevisiae