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Literature summary for 2.4.1.226 extracted from

  • Sakai, K.; Kimata, K.; Sato, T.; Gotoh, M.; Narimatsu, H.; Shinomiya, K.; Watanabe, H.
    Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage (2007), J. Biol. Chem., 282, 4152-4161.
    View publication on PubMed

Application

Application Comment Organism
medicine CSGalNAcT-1 plays a critical role in chondroitin sulfate biosynthesis in cartilage Homo sapiens
medicine CSGalNAcT-1 plays a critical role in chondroitin sulphate biosynthesis in cartilage Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information adenoviral gene delivery of the enzyme into intervertebral discs of 4-month -old ICR mice displays a substantial increase in the level of chondroitin sulfate biosynthesis Homo sapiens
additional information overexpression of the enzyme in chondrocytic cells further enhances chondroitin sulfate biosynthesis but not that of the aggrecan core protein, indicating that the enzyme activity is not saturated in the cells and that aggrecan synthesized in the overexpressing cells is heavier than the native molecule Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
cartilage by in situ hybridization and real time RT-PCR of developing cartilage, CSGal-NAcT-1 exhibits the highest level of expression among other glycosyltransferases involved in chondroitin sulphate synthesis Homo sapiens
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cartilage in heterozygote and homozygote aggrecan-null cartilage where aggrecan transcription is decreased, CSGal-NAcT-1 transcription diminishs accordingly Mus musculus
-

Synonyms

Synonyms Comment Organism
chondroitin sulfate N-acetylgalactosaminyltransferase-1
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Mus musculus
chondroitin sulfate N-acetylgalactosaminyltransferase-1
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Homo sapiens
CSGalNAcT-1
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Mus musculus
CSGalNAcT-1
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Homo sapiens