Literature summary for 2.4.1.226 extracted from

Sakai, K.; Kimata, K.; Sato, T.; Gotoh, M.; Narimatsu, H.; Shinomiya, K.; Watanabe, H.
Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage (2007), J. Biol. Chem., 282, 4152-4161.

Search for more literature for 2.4.1.226

Application

Application	Comment	Organism
medicine	CSGalNAcT-1 plays a critical role in chondroitin sulfate biosynthesis in cartilage	Homo sapiens
medicine	CSGalNAcT-1 plays a critical role in chondroitin sulphate biosynthesis in cartilage	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	adenoviral gene delivery of the enzyme into intervertebral discs of 4-month -old ICR mice displays a substantial increase in the level of chondroitin sulfate biosynthesis	Homo sapiens
additional information	overexpression of the enzyme in chondrocytic cells further enhances chondroitin sulfate biosynthesis but not that of the aggrecan core protein, indicating that the enzyme activity is not saturated in the cells and that aggrecan synthesized in the overexpressing cells is heavier than the native molecule	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cartilage	by in situ hybridization and real time RT-PCR of developing cartilage, CSGal-NAcT-1 exhibits the highest level of expression among other glycosyltransferases involved in chondroitin sulphate synthesis	Homo sapiens	-
cartilage	in heterozygote and homozygote aggrecan-null cartilage where aggrecan transcription is decreased, CSGal-NAcT-1 transcription diminishs accordingly	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
chondroitin sulfate N-acetylgalactosaminyltransferase-1	-	Mus musculus
chondroitin sulfate N-acetylgalactosaminyltransferase-1	-	Homo sapiens
CSGalNAcT-1	-	Mus musculus
CSGalNAcT-1	-	Homo sapiens

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Release 2023.1 (January 2023)