Application | Comment | Organism |
---|---|---|
medicine | CSGalNAcT-1 plays a critical role in chondroitin sulfate biosynthesis in cartilage | Homo sapiens |
medicine | CSGalNAcT-1 plays a critical role in chondroitin sulphate biosynthesis in cartilage | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | adenoviral gene delivery of the enzyme into intervertebral discs of 4-month -old ICR mice displays a substantial increase in the level of chondroitin sulfate biosynthesis | Homo sapiens |
additional information | overexpression of the enzyme in chondrocytic cells further enhances chondroitin sulfate biosynthesis but not that of the aggrecan core protein, indicating that the enzyme activity is not saturated in the cells and that aggrecan synthesized in the overexpressing cells is heavier than the native molecule | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cartilage | by in situ hybridization and real time RT-PCR of developing cartilage, CSGal-NAcT-1 exhibits the highest level of expression among other glycosyltransferases involved in chondroitin sulphate synthesis | Homo sapiens | - |
cartilage | in heterozygote and homozygote aggrecan-null cartilage where aggrecan transcription is decreased, CSGal-NAcT-1 transcription diminishs accordingly | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
chondroitin sulfate N-acetylgalactosaminyltransferase-1 | - |
Mus musculus |
chondroitin sulfate N-acetylgalactosaminyltransferase-1 | - |
Homo sapiens |
CSGalNAcT-1 | - |
Mus musculus |
CSGalNAcT-1 | - |
Homo sapiens |