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Literature summary for 2.4.1.222 extracted from

  • Pandey, A.; Harvey, B.M.; Lopez, M.F.; Ito, A.; Haltiwanger, R.S.; Jafar-Nejad, H.
    Glycosylation of specific Notch EGF repeats by O-Fut1 and Fringe regulates Notch signaling in Drosophila (2019), Cell Rep., 29, 2054-2066 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-GlcNAc + Notch epidermal growth factor-like sequence repeat-O-fucose Drosophila sp. (in: flies) the enzyme (Fringe) regulates fly Notch signaling by adding GlcNAc to O-fucose on Notch epidermal growth factor-like sequence repeats EGF8, -9, and -12 UDP + ?
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 ?

Organism

Organism UniProt Comment Textmining
Drosophila sp. (in: flies)
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-GlcNAc + Notch epidermal growth factor-like sequence repeat-O-fucose the enzyme (Fringe) regulates fly Notch signaling by adding GlcNAc to O-fucose on Notch epidermal growth factor-like sequence repeats EGF8, -9, and -12 Drosophila sp. (in: flies) UDP + ?
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 ?

Synonyms

Synonyms Comment Organism
fringe glycosyltransferase
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 Drosophila sp. (in: flies)

General Information

General Information Comment Organism
physiological function the enzyme (Fringe) regulates fly Notch signaling by adding GlcNAc to O-fucose on Notch EGF8, -9, and -12. Fringe-modified EGF8, -9, and -12 promote Delta-Notch signaling in wing vein formation. Fringe-modified EGF8 and -12 prevent cis-inhibition of Serrate by Notch in vivo Drosophila sp. (in: flies)