Literature summary for 2.4.1.221 extracted from

Li, Z.; Han, K.; Pak, J.E.; Satkunarajah, M.; Zhou, D.; Rini, J.M.
Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1 (2017), Nat. Chem. Biol., 13, 757-763 .

Search for more literature for 2.4.1.221

Cloned(Commentary)

Cloned (Comment)	Organism
-	Mus musculus

Crystallization (Commentary)

Crystallization (Comment)	Organism
X-ray crystal structure the enzyme (POFUT1) in complex with several EGF-like domains, including EGF12 and EGF26 of Notch	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GDP-L-fucose + Notch protein	Mus musculus	the enzyme fucosylates the epidermal growth factor (EGF)-like domains found in cell-surface and secreted glycoproteins including Notch and its ligands	GDP + fucosylated Notch protein	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q91ZW2	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Mus musculus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GDP-L-fucose + Notch protein	the enzyme fucosylates the epidermal growth factor (EGF)-like domains found in cell-surface and secreted glycoproteins including Notch and its ligands	Mus musculus	GDP + fucosylated Notch protein	-	?

Synonyms

Synonyms	Comment	Organism
Pofut1	-	Mus musculus
protein O-fucosyltransferase 1	-	Mus musculus

General Information

General Information	Comment	Organism
evolution	the highly correlated presence of POFUT1 and fucosylatable hEGFs has accompanied animal evolution	Mus musculus

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Release 2023.1 (January 2023)