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Literature summary for 2.4.1.221 extracted from

  • Okajima, T.; Matsuura, A.; Matsuda, T.
    Biological functions of glycosyltransferase genes involved in O-fucose glycan synthesis (2008), J. Biochem., 144, 1-6.
    View publication on PubMed
Search for more literature for 2.4.1.221

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface OFUT1 associates with Notch at the cell surface and promotes the constitutive endocytosis of Notch receptors Drosophila sp. (in: flies) 9986
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endoplasmic reticulum OFUT1 is required for the correct folding of Notch receptors in the endoplasmic reticulum and their subsequent trafficking to the cell surface Drosophila sp. (in: flies) 5783
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additional information adherens junction Drosophila sp. (in: flies)
-
-
plasma membrane OFUT1 promotes transcytosis of Notch from the apical plasma membrane to the adherens junctions Drosophila sp. (in: flies) 5886
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Organism

Organism UniProt Comment Textmining
Drosophila sp. (in: flies)
-
-
-
Mus musculus
-
-
-

Synonyms

Synonyms Comment Organism
O-fucosyltransferase 1
-
 Drosophila sp. (in: flies)
O-fucosyltransferase 1
-
 Mus musculus
OFUT1
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 Drosophila sp. (in: flies)
Pofut1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction loss of OFUT1 results in the phenotype that is characteristic of Notch loss of function. Loss of OFUT1 leads to the loss of cell surface expression and the intracellular accumulation of Notch receptors. Secretion of Notch is impaired in OFUT1-depleted S2 cells and the abnormal endoplasmic reticulum accumulation of Notch receptors is observed in Ofut1 mutant clones in Drosophila wing imaginal discs Drosophila sp. (in: flies)
malfunction loss of Pofut1 results in the phenotype that is characteristic of Notch loss of function Mus musculus
physiological function is essential for Notch signalling Mus musculus
physiological function is essential for Notch signalling. Ability of OFUT1 to promote Notch secretion does not depend on its enzyme activity, suggesting the chaperon-like role of OFUT1 Drosophila sp. (in: flies)