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Literature summary for 2.4.1.214 extracted from
- Highly sensitive cell-based assay system to monitor the sialyl Lewis X biosynthesis mediated by alpha1-3 fucosyltransferase-VII (2004), Biochem. Biophys. Res. Commun., 324, 98-107.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene FUT7, stable expression in MOLT-4 8H cells being induced by the recombinant enzyme in presence of mifepristone to produce sL2x epitopes, expression of Staphylococcus aureus protein A-human FucT-VII fusion protein in Spodoptera frugiperda Sf21 insect cells via the baculovirus infection system | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| panosialin K | specific inhibition of FucT-VII | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mn2+ | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | sialyl Lewis X biosynthesis is mediated by alpha1-3 fucosyltransferase-VIIS, the enzyme is essential for biosynthesis of P- and E-selectin binding ligands in T-cells | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| T-lymphoblastoma cell | - |
Homo sapiens | - |
| T-lymphocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GDP-beta-fucose + fetuin | - |
Homo sapiens | GDP + fucosylated fetuin | - |
? | |
| additional information | sialyl Lewis X biosynthesis is mediated by alpha1-3 fucosyltransferase-VIIS, the enzyme is essential for biosynthesis of P- and E-selectin binding ligands in T-cells | Homo sapiens | ? | - |
? | |
| additional information | development of a sensitive cell-based assay system to monitor FucT-VII mediated sialyl Lewis biosynthesis | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alpha1-3 fucosyltransferase-VII | - |
Homo sapiens |
| FucT-VII | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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