Literature summary for 2.4.1.212 extracted from

Yang, Y.M.; Noureddin, M.; Liu, C.; Ohashi, K.; Kim, S.Y.; Ramnath, D.; Powell, E.E.; Sweet, M.J.; Roh, Y.S.; Hsin, I.F.; Deng, N.; Liu, Z.; Liang, J.; Mena, E.; Shouhed, D.; Schwabe, R.F.; Jiang, D.; Lu, S.C.; Noble, P.W.; Seki, E.
Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis (2019), Sci. Transl. Med., 11, eaat9284 .

Search for more literature for 2.4.1.212

Application

Application	Comment	Organism
drug development	the enzyme actively synthesizes hyaluronan in hepatic stellate cells and promotes hepatic stellate cells activation and liver fibrosis through Notch1. Targeted hyaluronan inhibition may have potential to be an effective therapy for liver fibrosis	Homo sapiens
drug development	the enzyme actively synthesizes hyaluronan in hepatic stellate cells and promotes hepatic stellate cells activation and liver fibrosis through Notch1. Targeted hyaluronan inhibition may have potential to be an effective therapy for liver fibrosis	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q92819	-	-
Mus musculus	P70312	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatic stellate cell	-	Homo sapiens	-
hepatic stellate cell	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
Has2	-	Homo sapiens
Has2	-	Mus musculus
hyaluronan synthase 2	-	Homo sapiens
hyaluronan synthase 2	-	Mus musculus

Expression

Organism	Comment	Expression
Homo sapiens	hyaluronan synthase 2 expression is elevated in both human and murine liver fibrosis. The enzyme is transcriptionally up-regulated by transforming growth factor-beta through Wilms tumor 1 to promote fibrogenic, proliferative, and invasive properties of HSCs via CD44, Toll-like receptor 4, and newly identified downstream effector Notch1	up
Mus musculus	hyaluronan synthase 2 expression is elevated in both human and murine liver fibrosis. The enzyme is transcriptionally up-regulated by transforming growth factor-beta through Wilms tumor 1 to promote fibrogenic, proliferative, and invasive properties of HSCs via CD44, Toll-like receptor 4, and newly identified downstream effector Notch1	up

General Information

General Information	Comment	Organism
metabolism	hyaluronan synthase 2 expression is elevated in both human and murine liver fibrosis. The enzyme actively synthesizes hyaluronan in hepatic stellate cells and promotes activation of hepatic stellate cells and liver fibrosis through Notch1	Homo sapiens
metabolism	hyaluronan synthase 2 expression is elevated in both human and murine liver fibrosis. The enzyme actively synthesizes hyaluronan in hepatic stellate cells and promotes activation of hepatic stellate cells and liver fibrosis through Notch1	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)