Literature summary for 2.4.1.212 extracted from

Yoshida, H.; Aoki, M.; Komiya, A.; Endo, Y.; Kawabata, K.; Nakamura, T.; Sakai, S.; Sayo, T.; Okada, Y.; Takahashi, Y.
HYBID (alias KIAA1199/CEMIP) and hyaluronan synthase coordinately regulate hyaluronan metabolism in histamine-stimulated skin fibroblasts (2020), J. Biol. Chem., 295, 2483-2494 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q92819	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
skin fibroblast	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
Has2	-	Homo sapiens
hyaluronan synthase 2	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	histamine increases hyaluronan degradation by up-regulating HYBID (hyaluronan-binding protein) and down-regulating hyaluronan synthase 2 in human skin fibroblasts in a dose- and time-dependent manner and thereby decreases the total amounts and sizes of newly produced hyaluronan	down

General Information

General Information	Comment	Organism
metabolism	histamine controls hyaluronan metabolism by up-regulating HYBID (hyaluronan-binding protein) and down-regulating hyaluronan synthase 2 (HAS2) via distinct signaling pathways downstream of histamine receptor H1	Homo sapiens

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Release 2023.1 (January 2023)