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Literature summary for 2.4.1.212 extracted from

  • Passi, A.; Vigetti, D.; Buraschi, S.; Iozzo, R.V.
    Dissecting the role of hyaluronan synthases in the tumor microenvironment (2019), FEBS J., 286, 2937-2949 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.212

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92819
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Mus musculus P70312
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Source Tissue

Source Tissue Comment Organism Textmining
Hs-578T cell MDA-MB-231 and Hs-578T breast cancer cell line express higher levels of HAS2 mRNA and synthesize higher amounts of HA than breast cancer cell lines with a less aggressive phenotype, like MCF-7 Homo sapiens
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MCF-7 cell MDA-MB-231 and Hs-578T breast cancer cell line express higher levels of HAS2 mRNA and synthesize higher amounts of HA than breast cancer cell lines with a less aggressive phenotype, like MCF-7 Homo sapiens
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MDA-MB-231 cell MDA-MB-231 and Hs-578T breast cancer cell line express higher levels of HAS2 mRNA and synthesize higher amounts of HA than breast cancer cell lines with a less aggressive phenotype, like MCF-7. HAS2 is dramatically increased in bone metastases compared to the parental MDA-MB-231 cells Homo sapiens
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Synonyms

Synonyms Comment Organism
Has2
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 Homo sapiens
Has2
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 Mus musculus
hyaluronan synthases 2
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 Homo sapiens
hyaluronan synthases 2
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 Mus musculus

Expression

Organism Comment Expression
Homo sapiens MDAMB-231 and HS578T breast cancer cell line express higher levels of hyaluronan synthase 2 mRNA and synthesize higher amounts of hyaluronan than breast cancer cell lines with a less aggressive phenotype, like MCF-7 up

General Information

General Information Comment Organism
malfunction Has2-/- mice are embryonic lethal. Has2-/- embryos die between embryonic day 9.5 and 10.5 and exhibit severe cardiac and vascular abnormalities, in addition to yolk sac and somite deformities Mus musculus
physiological function enzyme expression has a pivotal role in cell motility and invasion. The enzyme regulates tumor progression and cell aggressiveness. Mammary tumor biopsies in which the enzyme (HAS2) is overexpressed display enhanced angiogenesis and inflammatory cells recruitment. HAS2 is a critical factor that induces epithelial-mesenchymal transition Homo sapiens