Cloned (Comment) | Organism |
---|---|
gene has2, quantitative real time PCR enzyme expression analysis, HAS2 expression is dependent on ceramide generated by neutral type 2 sphingomyelinase, nSMase2, as shown by treatment with C2-ceramide that decreases HAS2 expression in murine fro/fro fibroblasts | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ceramide | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P70312 | isozyme HAS2, gene has2 | - |
Mus musculus 129/Sv | P70312 | isozyme HAS2, gene has2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
Has2 | - |
Mus musculus |
hyaluronan synthase-2 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | recombinant hyaluronan synthase-2 upregulation protects smpd3-deficient fibroblasts against cell death induced by nutrient deprivation, but not against apoptosis evoked by human oxidized LDL. Resistance of fro/fro cells to starvation-induced apoptosis is associated with an increased expression of hyaluronan synthase 2 (HAS2) mRNAs and protein, which is inhibited by ceramide. The protective mechanism of HAS2 involves an increased expression of the heat-shock protein Hsp72, a chaperone with antiapoptotic activity. Antiapoptotic properties of HAS2 , overview | Mus musculus |