Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00219 | isoform HAS3 | - |
Homo sapiens | Q92819 | isoform HAS2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
SW-620 cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | inhibition of HAS2 expression by siRNA decreases matrix metalloprotein MMP-7 expression by about 20%, and dramaticlly decreases MMP-7 protein, and enzymatic activity. HAS isoforms and hyaluronan may mediate cellular invasion via changes in matrix metalloprotein MMP-7 expression | Homo sapiens |
physiological function | inhibition of HAS2 expression by siRNA decreases matrix metalloprotein MMP-7 expression by about 30%, and dramaticlly decreases MMP-7 protein, and enzymatic activity. HAS isoforms and hyaluronan may mediate cellular invasion via changes in matrix metalloprotein MMP-7 expression | Homo sapiens |