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Literature summary for 2.4.1.212 extracted from

  • Meran, S.; Thomas, D.; Stephens, P.; Martin, J.; Bowen, T.; Phillips, A.; Steadman, R.
    Involvement of hyaluronan in regulation of fibroblast phenotype (2007), J. Biol. Chem., 282, 25687-25697.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
interleukin-1beta
-
Homo sapiens
transforming growth factor-beta1 TGF-beta1 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
the coding sequence of HAS1 is cloned into the vector pCR3.1 for transfection of fibroblasts Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
HAS1 siRNA
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan] Homo sapiens
-
UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]
-
?
UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan] Homo sapiens
-
UDP + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast oral and dermal fibroblast Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]
-
Homo sapiens UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]
-
?
UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]
-
Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]
-
?

Synonyms

Synonyms Comment Organism
HAS
-
Homo sapiens
hyaluronan synthase
-
Homo sapiens