Literature summary for 2.4.1.212 extracted from

Rilla, K.; Siiskonen, H.; Spicer, A.P.; Hyttinen, J.M.; Tammi, M.I.; Tammi, R.H.
Plasma membrane residence of hyaluronan synthase is coupled to its enzymatic activity (2005), J. Biol. Chem., 280, 31890-31897.

Search for more literature for 2.4.1.212

Cloned(Commentary)

Cloned (Comment)	Organism
functional expression of isozymes HAS2 and HAS3 in rat epidermal keratinocytes as N-terminally GFP-tagged protein, recombinant isozymes GFP-HAS2 and GFP-HAS3 travel through endoplasmic reticulum, Golgi, plasma membrne, and endocytic vesicles, expression of inactive GFP-tagged HAS3 D216A mutant and of GFP-tagged HAS3-deletion mutants in keratinocytes	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
D216A	site-directed mutagenesis, isozyme HAS3, inactive mutant	Mus musculus
additional information	construction of deletion mutants of isozyme HAS3	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
4-Methylumbelliferone	changes the localization of the enzyme by preventing its association with the plasma membrane	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endocytic vesicle	-	Mus musculus	30139	-
endoplasmic reticulum	-	Mus musculus	5783	-
Golgi apparatus	-	Mus musculus	5794	-
additional information	recombinant isozymes GFP-HAS2 and GFP-HAS3 travel through endoplasmic reticulum, Golgi, plasma membrane, and endocytic vesicles in keratinocytes	Mus musculus	-	-
plasma membrane	integral, plasma membrane residence of hyaluronan synthase is coupled to its enzymatic activity	Mus musculus	5886	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	isozymes HAS2 and HAS3	-

Synonyms

Synonyms	Comment	Organism
HAS	-	Mus musculus

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Release 2023.1 (January 2023)