Cloned (Comment) | Organism |
---|---|
gene GPI2 encodes for one of the six accessory subunits of the GPI-N-acetylglucosaminyltransferase complex | Saccharomyces cerevisiae |
gene GPI2 encodes for one of the six accessory subunits of the GPI-N-acetylglucosaminyltransferase complex | Candida albicans |
Protein Variants | Comment | Organism |
---|---|---|
additional information | recombinant expression of Candida albicans GPI2 subunit in a Saccharomyces cerevisiae GPI2 subunit conditional lethal mutant cannot restore its growth defects. In mutants where CaGPI19 is downregulated, a downregulation of CaGPI2 is unable to restore CaERG11 levels, suggesting that CaGpi19, rather than CaGpi2 is the major partner in the cross-talk with CaErg11 | Candida albicans |
additional information | Saccharomyces cerevisiae Gpi2, an accessory subunit of the enzyme catalyzing the first step of glycosylphosphatidylinositol (GPI) anchor biosynthesis, selectively complements some of the functions of its homologue in Candida albicans | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida albicans | Q5A6L6 | enzyme complex subunit GPI2 | - |
Saccharomyces cerevisiae | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
GPI-GnT | - |
Saccharomyces cerevisiae |
GPI-GnT | - |
Candida albicans |
GPI-N-acetylglucosaminyltransferase | - |
Saccharomyces cerevisiae |
GPI-N-acetylglucosaminyltransferase | - |
Candida albicans |
GPI2 | - |
Candida albicans |
General Information | Comment | Organism |
---|---|---|
malfunction | recombinant expression of Candida albicans GPI2 subunit in a Scaccharomyces cerevisiae GPI2 subunit conditional lethal mutant cannot restore its growth defects | Saccharomyces cerevisiae |
malfunction | Saccharomyces cerevisiae Gpi2, an accessory subunit of the enzyme catalyzing the first step of glycosylphosphatidylinositol (GPI) anchor biosynthesis, selectively complements some of the functions of its homologue in Candida albicans | Candida albicans |
physiological function | Saccharomyces cerevisiae enzyme subunit Gpi2 is an accessory subunit of the enzyme that catalyzes the first step of glycosylphosphatidylinositol (GPI) anchor biosynthesis. Saccharomyces cerevisiae enzyme subunit Gpi2 subunit physically interacts with and negatively modulates Ras signaling, while enzyme subunit Gpi2 from Candida albicans is a positive modulator of Ras signaling | Saccharomyces cerevisiae |
physiological function | the GPI-Nacetylglucosaminyltransferase (GPI-GnT) enzyme complex catalyzes the first and committing step of the pathway in Candida albicans involving transfer of N-acetylglucosamine from UDP-GlcNAc to phosphatidylinositol. Saccharomyces cerevisiae subunit Gpi2 enzyme subunit physically interacts with and negatively modulates Ras signaling, while enzyme subunit Gpi2 from Candida albicans is a positive modulator of Ras signaling. The effect of Candida albicans GPI2 subunit on sterol biosynthesis Candida albicans is independent of its interaction with the GPI-GnT enzyme complex and Ras signaling pathways | Candida albicans |