Literature summary for 2.4.1.198 extracted from

Victoria, G.S.; Yadav, B.; Hauhnar, L.; Jain, P.; Bhatnagar, S.; Komath, S.S.
Mutual co-regulation between GPI-N-acetylglucosaminyltransferase and ergosterol biosynthesis in Candida albicans (2012), Biochem. J., 443, 619-625.

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Organism

Organism	UniProt	Comment	Textmining
Candida albicans	-	gene CaGPI19, encoding an accessory subunit of the enzyme complex	-
Candida albicans BWP17	-	gene CaGPI19, encoding an accessory subunit of the enzyme complex	-

Synonyms

Synonyms	Comment	Organism
GPI-N-acetylglucosaminyltransferase	-	Candida albicans

Expression

Organism	Comment	Expression
Candida albicans	downregulation of ERG11 downregulates CaGPI19 and GPI biosynthesis	down

General Information

General Information	Comment	Organism
malfunction	depletingCaGpi19p, an accessory subunit of the enzyme complex that initiates GPI biosynthesis, specifically down-regulates ERG11, altering ergosterol levels and drug response. ERG11 down-regulation is not due to general cell wall defects or GPI deficiency. CaGPI19 mutants show increased cAMP/PKA signalling	Candida albicans
physiological function	the enzyme is part of the enzyme complex that initiates glycosylphosphatidylinositol, GPI, biosynthesis, it catalyzes the first step of GPI anchor biosynthesis. CaGPI19 appears to be mutually regulated with ERG11	Candida albicans

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Release 2023.1 (January 2023)