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Literature summary for 2.4.1.198 extracted from

  • Newman, H.A.; Romeo, M.J.; Lewis, S.E.; Yan, B.C.; Orlean, P.; Levin, D.E.
    Gpi19, the Saccharomyces cerevisiae homologue of mammalian PIG-P, is a subunit of the initial enzyme for glycosylphosphatidylinositol anchor biosynthesis (2005), Eukaryot. Cell, 4, 1801-1807.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information a gpi19 deletion allele that lacks nearly the entire coding sequence in the EG123 strain background confirmed the lethality of this mutation Saccharomyces cerevisiae
additional information a set of temperature-sensitive gpi19 allels is created using error-prone PCR. All of the gpi19 alleles, with the exception of gpi19-4, are osmotically remedial. The gpi19 mutants are hypersensitive to zymolyase treatment. The least severely impaired alleles of gpi19 (gpi19-1 and gpi19-2) are suppressed for their growth defects at restrictive temperature by either GFA1 overexpression or exogenous glucosamine. The gpi19 mutants display weak filamentation phenotypes and invasive growth, which is enhanced by the inclusion of sorbitol in the medium to suppress their growth defects. Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Synonyms

Synonyms Comment Organism
DR437w encodes an essential subunit of the yeast glycosylphosphatidylinositol N-acetylglucosaminyltransferase. The C-terminus is cytoplasmic, the N-terminus is also cytoplasmic and both transmembrane domains pass through the ER membrane. The N-terminal half (at least 60 residues) is dispensable for functions at low temperatures Saccharomyces cerevisiae
GPI-GlcNAc transferase
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Saccharomyces cerevisiae
GPI19 YDR437w (encodes an essential subunit of the yeast glycosylphosphatidylinositol N-acetylglucosaminyltransferase) is also called GPI19 (for glycosylphosphatidylinositol anchor 19) Saccharomyces cerevisiae