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Literature summary for 2.4.1.183 extracted from

  • He, X.; Li, S.; Kaminskyj, S.G.W.
    Overexpression of Aspergillus nidulans alpha-1,3-glucan synthase increases cellular adhesion and causes cell wall defects (2018), Med. Mycol., 56, 645-648 .
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
gene agsB, quantitative PCR enzyme expression analysis, constitutive overexpression in Aspergillus nidulans. The high level of agsB expression is deleterious Aspergillus nidulans

Protein Variants

Protein Variants Comment Organism
additional information generation of an Aspergillus nidulans alpha-1,3-glucan in constitutive overexpression strain. Constitutive high-level alpha-1,3-glucan synthase activity increases hyphal wall thickness, but colonies grow slowly and sporulate poorly and have much higher adhesion to hydrophobic materials. In contrast to the wild-type strain, the overexpression strain forms a biofilm-like structure in plastic culture wells that is as adhesive as wild-type Aspergillus fumigatus. The high level of agsB expression is deleterious. Phenotype, overview Aspergillus nidulans

Localization

Localization Comment Organism GeneOntology No. Textmining
cell wall
-
 Aspergillus nidulans 5618
-

Organism

Organism UniProt Comment Textmining
Aspergillus nidulans
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mycelium
-
 Aspergillus nidulans
-

Synonyms

Synonyms Comment Organism
agsB
-
 Aspergillus nidulans

General Information

General Information Comment Organism
malfunction overexpression of Aspergillus nidulans alpha-1,3-glucan synthase increases cellular adhesion and causes cell wall defects Aspergillus nidulans
physiological function alpha-1,3-glucan has important roles in fungal cellular adhesion and may contribute to fungal pathogenesis Aspergillus nidulans