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Literature summary for 2.4.1.175 extracted from

  • Momose, T.; Yoshimura, Y.; Harumiya, S.; Isobe, K.; Kito, M.; Fukushima, M.; Kato, H.; Nakayama, J.
    Chondroitin sulfate synthase 1 expression is associated with malignant potential of soft tissue sarcomas with myxoid substance (2016), Hum. Pathol., 50, 15-23 .
    View publication on PubMed

Application

Application Comment Organism
medicine CHSY1 expression is closely associated with malignant potential of soft tissue sarcomas with myxoid substance Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene CHSY1, quantitative RT-PCR enzyme expression analysis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86X52
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Source Tissue

Source Tissue Comment Organism Textmining
chondrocyte in nontumorous cartilages Homo sapiens
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fibromyxoid sarcoma cell low-grade Homo sapiens
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additional information CHSY1 is strongly expressed in myxofibrosarcoma and malignant peripheral nerve sheath tumor compared with other tumors and significantly associated with higher, rather than lower-grade tumors. High expression of CHSY1 is also significantly associated with poorer patient outcomes and higher stages, overview. Enzyme CHSY1 expression correlates with malignant potential of soft tissue sarcomas with myxoid substance. Immunohistochemical analysis of CHSY1 in soft tissue sarcomas with myxoid substance Homo sapiens
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myxofibrosarcoma cell
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Homo sapiens
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myxoid liposarcoma cell
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Homo sapiens
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peripheral nerve sheath cancer cell malignant Homo sapiens
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sarcoma cell soft tissue sarcomas. Soft tissue sarcoma is a malignant tumor of nonepithelial extraskeletal origin classified by specific, differentiated cell types Homo sapiens
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Synonyms

Synonyms Comment Organism
chondroitin sulfate synthase 1
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Homo sapiens
CHSY1
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Homo sapiens
CSS1
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Homo sapiens
More see also EC 2.4.1.226 Homo sapiens

General Information

General Information Comment Organism
physiological function the glycosyltransferase chondroitin sulfate synthase 1 (CHSY1) specifically functions in biosynthesis of the glycans chondroitin sulfate. The bifunctional CHSY1 exhibits both GlcAT-II and GalNAc-II activities, thus forming the GlcA-GalNAc disaccharide structure specific for chondroitin sulfate Homo sapiens