Application | Comment | Organism |
---|---|---|
medicine | CHSY1 expression is closely associated with malignant potential of soft tissue sarcomas with myxoid substance | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene CHSY1, quantitative RT-PCR enzyme expression analysis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q86X52 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
chondrocyte | in nontumorous cartilages | Homo sapiens | - |
fibromyxoid sarcoma cell | low-grade | Homo sapiens | - |
additional information | CHSY1 is strongly expressed in myxofibrosarcoma and malignant peripheral nerve sheath tumor compared with other tumors and significantly associated with higher, rather than lower-grade tumors. High expression of CHSY1 is also significantly associated with poorer patient outcomes and higher stages, overview. Enzyme CHSY1 expression correlates with malignant potential of soft tissue sarcomas with myxoid substance. Immunohistochemical analysis of CHSY1 in soft tissue sarcomas with myxoid substance | Homo sapiens | - |
myxofibrosarcoma cell | - |
Homo sapiens | - |
myxoid liposarcoma cell | - |
Homo sapiens | - |
peripheral nerve sheath cancer cell | malignant | Homo sapiens | - |
sarcoma cell | soft tissue sarcomas. Soft tissue sarcoma is a malignant tumor of nonepithelial extraskeletal origin classified by specific, differentiated cell types | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
chondroitin sulfate synthase 1 | - |
Homo sapiens |
CHSY1 | - |
Homo sapiens |
CSS1 | - |
Homo sapiens |
More | see also EC 2.4.1.226 | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the glycosyltransferase chondroitin sulfate synthase 1 (CHSY1) specifically functions in biosynthesis of the glycans chondroitin sulfate. The bifunctional CHSY1 exhibits both GlcAT-II and GalNAc-II activities, thus forming the GlcA-GalNAc disaccharide structure specific for chondroitin sulfate | Homo sapiens |