Literature summary for 2.4.1.175 extracted from

Adhikara, I.M.; Yagi, K.; Mayasari, D.S.; Ikeda, K.; Kitagawa, H.; Miyata, O.; Igarashi, M.; Hatakeyama, K.; Asada, Y.; Hirata, K.I.; Emoto, N.
Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration (2019), Biochem. Biophys. Res. Commun., 509, 89-95 .

Search for more literature for 2.4.1.175

Application

Application	Comment	Organism
medicine	gene ChGn-2 may serve as a plausible target to treat atherosclerotic-related diseases in humans	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	deletion of the ChGn-2 gene significantly reduces LDL retention in the DIT mouse model. Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration. A functional assay of ASMCs prepared from ChGn-2-/- mice displays abrogation of platelet-derived growth factor (PDGF)-mediated migration via reduced PDGF receptor phosphorylation. Evaluation of LDL retention in a diffuse intimal thickening (DIT) model using partial carotid ligation on ChGn-2/LDL receptor double knockout (ChGn-2-/- / LDLr-/-) mice	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
Golgi apparatus	-	Homo sapiens	5794	-
Golgi apparatus	-	Mus musculus	5794	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8IZ52	-	-
Mus musculus	Q6IQX7	-	-
Mus musculus C57BL/6J	Q6IQX7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
aortic smooth muscle cell	ASMC	Homo sapiens	-
aortic smooth muscle cell	ASMC	Mus musculus	-
coronary artery	-	Homo sapiens	-
additional information	ChGn-2 expression on early and advanced atherosclerotic lesions, overview	Homo sapiens	-
vascular system	vascular wall	Homo sapiens	-
vascular system	vascular wall	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
ChGn-2	-	Homo sapiens
ChGn-2	-	Mus musculus
chondroitin sulfate N-acetylgalactosaminyltransferase-2	-	Homo sapiens
chondroitin sulfate N-acetylgalactosaminyltransferase-2	-	Mus musculus
CHPF	-	Homo sapiens
More	see also EC 2.4.1.226	Homo sapiens
More	see also EC 2.4.1.226	Mus musculus

General Information

General Information	Comment	Organism
malfunction	chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell (ASMC) migration through attenuating PDGFR phosphorylation. Effects of CHPF gene deletion on the development of atherosclerosis, overview	Homo sapiens
malfunction	chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration. Effects of ChGn-2 gene deletion on the development of atherosclerosis, overview	Mus musculus
physiological function	chondroitin sulfate N-acetylgalactosaminyltransferase-2 (ChGn-2) is a vital Golgi transferase that participates in enzymatic elongation of GAGs. ChGn-2 is functionally involved in the progression of atherosclerosis both in its early and advanced stages. Crucial contributions of ChGn-2 for LDL retention in the intima. Platelet-derived growth factor (PDGF) signaling is heavily involved in the development of plaques and directly regulates SMCs via platelet-derived growth factor receptor, PDGFR-beta, phosphorylation to promote phenotypic changes including smooth muscle cell migration, enzyme chondroitin sulfate N-acetylgalactosaminyltransferase-2 has a regulatory function	Homo sapiens
physiological function	chondroitin sulfate N-acetylgalactosaminyltransferase-2 (ChGn-2) is a vital Golgi transferase that participates in enzymatic elongation of GAGs. ChGn-2 is functionally involved in the progression of atherosclerosis both in its early and advanced stages. Crucial contributions of ChGn-2 for LDL retention in the intima. Platelet-derived growth factor (PDGF) signaling is heavily involved in the development of plaques and directly regulates SMCs via platelet-derived growth factor receptor, PDGFR-beta, phosphorylation to promote phenotypic changes including smooth muscle cell migration, enzyme chondroitin sulfate N-acetylgalactosaminyltransferase-2 has a regulatory function	Mus musculus

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Release 2023.1 (January 2023)