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Literature summary for 2.4.1.175 extracted from

  • Izumikawa, T.; Koike, T.; Shiozawa, S.; Sugahara, K.; Tamura, J.; Kitagawa, H.
    Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members (2008), J. Biol. Chem., 283, 11396-11406.
    View publication on PubMed
Search for more literature for 2.4.1.175

Cloned(Commentary)

Cloned (Comment) Organism
GFP-tagged and DsRed-monomer tagged enzyme expressed in HeLa cells Homo sapiens
soluble form of the enzyme lacking the first 57 amino acids expressed as protein A fusion protein in COS-1 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Homo sapiens 5794
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens experimental data suggest that enzyme acts as a chondroitin polymerase through its interaction with other ChSy family members in the Golgi apparatus ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q70JA7
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant protein using protein A-tag Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
colon
-
 Homo sapiens
-
heart
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
leukocyte from peripheral blood Homo sapiens
-
liver
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
skeletal muscle
-
 Homo sapiens
-
small intestine
-
 Homo sapiens
-
spleen
-
 Homo sapiens
-
thymus
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GlcUAbeta1-3Galbeta1-O-C2H4NH-benzyloxycarbonyl + UDP-glucuronic acid
-
 Homo sapiens ?
-
 ?
GlcUAbeta1-3Galbeta1-O-C2H4NH-benzyloxycarbonyl + UDP-N-acetyl-D-galactosamine
-
 Homo sapiens ?
-
 ?
GlcUAbeta1-3Galbeta1-O-naphthalenemethanol + UDP-glucuronic acid
-
 Homo sapiens ?
-
 ?
GlcUAbeta1-3Galbeta1-O-naphthalenemethanol + UDP-N-acetyl-D-galactosamine
-
 Homo sapiens ?
-
 ?
additional information experimental data suggest that enzyme acts as a chondroitin polymerase through its interaction with other ChSy family members in the Golgi apparatus Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
chondroitin sulfate glucuronyltransferase
-
 Homo sapiens
chondroitin synthase-3 based on the experimental results CSGlcA-T renamed into chondroitin synthase-3 Homo sapiens
ChSy-3
-
 Homo sapiens
CSGlcA-T
-
 Homo sapiens