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Literature summary for 2.4.1.175 extracted from

  • Kitagawa, H.; Uyama, T.; Sugahara, K.
    Molecular cloning and expression of a human chondroitin synthase (2001), J. Biol. Chem., 276, 38721-38726.
    View publication on PubMed
Search for more literature for 2.4.1.175

Cloned(Commentary)

Cloned (Comment) Organism
genomic organization and chromosome localization, functional expression as soluble protein fused to protein A IgG-binding domain in COS-1 cells, secretion into the medium Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane type II membrane protein topology Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86X52
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
heart
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
leukocyte peripheral blood Homo sapiens
-
leukocyte high content Homo sapiens
-
liver
-
 Homo sapiens
-
lung high content Homo sapiens
-
peripheral blood
-
 Homo sapiens
-
placenta very high content Homo sapiens
-
skeletal muscle
-
 Homo sapiens
-
spleen high content Homo sapiens
-
thymus
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity Homo sapiens ?
-
 ?
additional information chondroitin sulfate A and D are very poor acceptor substrates Homo sapiens ?
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)3 low activity Homo sapiens UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)2
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)4 low activity Homo sapiens UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)3
-
 ?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide best acceptor substrate Homo sapiens UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide transfer in beta-1,4-linkage ?
UDP-N-acetyl-D-galactosamine + chondroitin sulfate C 11% activity compared to chondroitin Homo sapiens UDP + N-acetyl-D-galactosaminyl chondroitin sulfate C
-
 ?

Synonyms

Synonyms Comment Organism
More the enzyme also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
 assay at Homo sapiens