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Literature summary for 2.4.1.175 extracted from

  • Uyama, T.; Kitagawa, H.; Tanaka, J.; Tamura, J.i.; Ogawa, T.; Sugahara, K.
    Molecular cloning and expression of a second chondroitin N-acetylgalactosaminyltransferase involved in the initiation and elongation of chondroitin/dermatan sulfate (2003), J. Biol. Chem., 278, 3072-3078.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
DNA sequence determination, genomic organization and chromosome localization, functional expression as soluble protein fused to protein A IgG-binding domain in COS-1 cells, secretion into the medium Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane type II membrane protein topology Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
95000
-
x * 95000, recombinant enzyme, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-alpha-D-galactosamine + chondroitin oligosaccharide Homo sapiens involved in chondroitin biosynthesis UDP + N-acetyl-beta-D-galactosaminyl chondroitin oligosaccharide
-
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide Homo sapiens involved in chondroitin sulfate biosynthesis: elongation of growing chondroitin sulfate chain UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N6G5 chondroitin N-acetylgalactosaminyltransferase II
-
Homo sapiens Q8TDX6 chondroitin N-acetylgalactosaminyltransferase I, not N-acetylgalactosaminyltransferase I EC 2.4.1.174
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein 2 potential N-glycosylation sites, either one or both of which are used in COS-1 cells during expression of the recombinant fusion protein Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
-
Homo sapiens
-
lung
-
Homo sapiens
-
peripheral blood
-
Homo sapiens
-
skeletal muscle
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme shows no 3-beta-glucuronosyltransferase activity, EC 2.4.1.226 Homo sapiens ?
-
?
additional information the enzyme also has N-acetylgalactosaminyltransferase I activity, EC 2.4.1.174 Homo sapiens ?
-
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin oligosaccharide involved in chondroitin biosynthesis Homo sapiens UDP + N-acetyl-beta-D-galactosaminyl chondroitin oligosaccharide
-
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide involved in chondroitin sulfate biosynthesis: elongation of growing chondroitin sulfate chain Homo sapiens UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide
-
?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
-
Homo sapiens UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
-
?

Subunits

Subunits Comment Organism
? x * 95000, recombinant enzyme, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
chondroitin galactosaminyltransferase
-
Homo sapiens
More the enzyme also has N-acetylgalactosaminyltransferase I activity, EC 2.4.1.174 Homo sapiens
More the human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase co-polymerases can be found in Pasteurella multocida and Escherichia coli. Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
assay at Homo sapiens