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Literature summary for 2.4.1.174 extracted from

  • Clausen, T.M.; Pereira, M.A.; Al Nakouzi, N.; Oo, H.Z.; Agerbaek, M.O.; Lee, S.; Oerum-Madsen, M.S.; Kristensen, A.R.; El-Naggar, A.; Grandgenett, P.M.; Grem, J.L.; Hollingsworth, M.A.; Holst, P.J.; Theander, T.; Sorensen, P.H.; Daugaard, M.; Salanti, A.
    Oncofetal chondroitin sulfate glycosaminoglycans are key players in integrin signaling and tumor cell motility (2016), Mol. Cancer Res., 14, 1288-1299 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
drug development functional link of oncofetal chondroitin sulfate glycosaminoglycan chains (ofCS) modifications with cancer cell motility, chondroitin sulfate synthesis knockdown is a therapeutic cancer target Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information saturating concentrations of rVAR2 inhibit downstream integrin signaling, which is mimicked by knockdown of the core chondroitin sulfate (CS) synthesis enzymes beta-1,3-glucuronyltransferase 1 (B3GAT1) and chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1) via siRNA. The oncofetal chondroitin sulfate glycosaminoglycans (ofCS) modification is highly expressed in both human and murine metastatic lesions in situ and pre-incubation or early intravenous treatment of tumor cells with rVAR2-inhibited seeding and spreading of tumor cells in mice Homo sapiens
additional information saturating concentrations of rVAR2 inhibit downstream integrin signaling, which is mimicked by knockdown of the core CS synthesis enzymes beta-1,3-glucuronyltransferase 1 (B3GAT1) and chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1) via siRNA. The oncofetal chondroitin sulfate glycosaminoglycan chains (ofCS) modification is highly expressed in both human and murine metastatic lesions in situ and pre-incubation or early intravenous treatment of tumor cells with rVAR2-inhibited seeding and spreading of tumor cells in mice Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8TDX6
-
-
Mus musculus Q8BJQ9
-
-
Mus musculus C57BL/6 Q8BJQ9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
carcinoma cell
-
 Homo sapiens
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carcinoma cell
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 Mus musculus
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pancreatic cancer cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
chondroitin sulfate N-acetylgalactosaminyltransferase 1
-
 Homo sapiens
chondroitin sulfate N-acetylgalactosaminyltransferase 1
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 Mus musculus
CSGalNAcT1
-
 Homo sapiens
CSGalNAcT1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction saturating concentrations of rVAR2 inhibit downstream integrin signaling, which is mimicked by knockdown of the core chondroitin sulfate (CS) synthesis enzymes beta-1,3-glucuronyltransferase 1 (B3GAT1) and chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1). rVAR2 inhibits cellular migration, invasion, and anchorage independent growth in cancer. rVAR2 interacts with chondroitin sulfate glycosaminoglycan (ofCS)-modified proteoglycans Mus musculus
malfunction saturating concentrations of rVAR2 inhibit downstream integrin signaling, which is mimicked by knockdown of the core CS synthesis enzymes beta-1,3-glucuronyltransferase 1 (B3GAT1) and chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1). rVAR2 inhibits cellular migration, invasion, and anchorage independent growth in cancer. rVAR2 interacts with chondroitin sulfate glycosaminoglycan (ofCS)-modified proteoglycans Homo sapiens
physiological function enzymes beta-1,3-glucuronyltransferase 1 (B3GAT1) and chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1) are key players in the core chondroitin sulfate (CS) synthesis. Oncofetal chondroitin sulfate glycosaminoglycans (ofCSs) are key players in integrin signaling and tumor cell motility, overview Mus musculus
physiological function the enzymes beta-1,3-glucuronyltransferase 1 (B3GAT1) and chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1) are key players in the core chondroitin sulfate (CS) synthesis. Oncofetal chondroitin sulfate glycosaminoglycans (ofCSs) are key players in integrin signaling and tumor cell motility, overview Homo sapiens