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Literature summary for 2.4.1.174 extracted from

  • Wilson, D.G.; Phamluong, K.; Lin, W.Y.; Barck, K.; Carano, R.A.; Diehl, L.; Peterson, A.S.; Martin, F.; Solloway, M.J.
    Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning (2012), Dev. Biol., 363, 413-425.
    View publication on PubMed
Search for more literature for 2.4.1.174

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
embryo
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 Mus musculus
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skeletal system expression of Chsy1 is up-regulated in skeletal elements Mus musculus
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Synonyms

Synonyms Comment Organism
chondroitin sulfate synthase 1
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 Mus musculus
CHSY1
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 Mus musculus
CSS1
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 Mus musculus

General Information

General Information Comment Organism
malfunction Chsy1-/- mice show a profound limb patterning defect in which orthogonally shifted ectopic joints form in the distal digits. Associated with the digit-patterning defect is a shift in cell orientation and an imbalance in chondroitin sulfation. Chondrogenesis is impaired as early as E13.5 in Chsy1-/- embryos. Ectopic, split digit phenotype, overview Mus musculus
physiological function Chsy1 catalyzes the extension of chondroitin and dermatan sulfate glycosaminoglycans and is an essential regulator of joint patterning Mus musculus