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Literature summary for 2.4.1.174 extracted from

  • Watanabe, Y.; Takeuchi, K.; Higa Onaga, S.; Sato, M.; Tsujita, M.; Abe, M.; Natsume, R.; Li, M.; Furuichi, T.; Saeki, M.; Izumikawa, T.; Hasegawa, A.; Yokoyama, M.; Ikegawa, S.; Sakimura, K.; Amizuka, N.; Kitagawa, H.; Igarashi, M.
    Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development (2010), Biochem. J., 432, 47-55.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
CSGalNAcT1 expression in C57BL/6 ES cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of CSGalNAcT1-null mice by homologous recombination using an embryonic stem cell line, RENKA, developed from the wild-type C57BL/6N strain Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-
Mus musculus C57BL/6N
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
cartilage
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 Mus musculus
-

Synonyms

Synonyms Comment Organism
chondroitin sulfate N-acetylgalactosaminyltransferase-1
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 Mus musculus
CS N-acetylgalactosaminyltransferase 1
-
 Mus musculus
CSGalNAcT1
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 Mus musculus

General Information

General Information Comment Organism
malfunction chondroitin sulfate production is reduced by approximately half in CSGalNAcT1-null mice, and the amount of short-chain CS is also reduced compared to wild-type mice. CSGalNAcT1-null mice have reduced skeletal growth, thickness of the growth plate is reduced, and the cartilage of the null mice is significantly smaller than that of wild-type mice, phenotype, overview Mus musculus
physiological function chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development Mus musculus