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Literature summary for 2.4.1.17 extracted from
- Coexpression of human hepatic uridine diphosphate glucuronosyltransferase proteins implications for ontogenetic mechanisms and isoform coregulation (2020), J. Clin. Pharm., 60, 722-733 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
| microsome | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-glucuronate + acceptor | Homo sapiens | - |
UDP + acceptor beta-D-glucuronoside | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O60656 | - |
- |
| Homo sapiens | P16662 | - |
- |
| Homo sapiens | P19224 | - |
- |
| Homo sapiens | P22309 | - |
- |
| Homo sapiens | P22310 | - |
- |
| Homo sapiens | P35503 | - |
- |
| Homo sapiens | Q3SY77 | - |
- |
| Homo sapiens | Q6NUS8 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | protein expression of UGT isozymes 1A1, 1A3, 1A4, 1A6, 1A9, 2B7, 3A1, and 3A2 using western blots from 164 healthy human liver samples, comparing expression with age and sex, relative protein levels among major human hepatic UGTs, detailed overview | Homo sapiens | - |
| additional information | in children aged below 18 years, UGT1A4 and UGT1A9 protein expressions is significantly correlated, but not for adults aged above 18 years. UGT1A3 expression is always significantly correlated with other UGT1A isoforms in all adults aged below 18 years. Expression of UGT1A6 and UGT1A9 correlates in the entire sample population | Homo sapiens | - |
| additional information | in children aged below 18 years, UGT1A4 and UGT1A9 protein expressions is significantly correlated, but not for adults aged above 18 years. UGT1A3 expression is always significantly correlated with other UGT1A isoforms in all adults aged below 18 years. In individuals aged above 12 years, expression of UGT1A1/1A4, UGT1A1/1A6,UGT1A1/1A9,and UGT1A4/1A6 significantly correlates, which is not observed in children aged below 12 years. In contrast, UGT1A4/2B7 show significant correlation in children aged below 12 years,but not in individuals aged above 12 years,and this is observed in female but not male individuals. UGT1A4 and UGT2B7 correlate more highly in male than female individuals. UGT1A4 and UGT1A6 protein correlate more significantly in female than male individuals | Homo sapiens | - |
| additional information | isozyme UGT3A1 expression significantly increases with age from childhood to age over 65 years. UGT1A3 expression is always significantly correlated with other UGT1A isoforms in all adults aged below 18 years. Expression of UGT3A1 and UGT3A2 correlates in the entire sample population, but UGT3As do not correlate with other UGTs. UGT3A1/3A2 correlate more highly in male than female individuals | Homo sapiens | - |
| additional information | isozyme UGT3A2 expression significantly increases with age from childhood to age over 65 years. UGT1A3 expression is always significantly correlated with other UGT1A isoforms in all adults aged below 18 years. Expression of UGT3A1 and UGT3A2 correlates in the entire sample population, but UGT3As do not correlate with other UGTs. UGT3A1/3A2 correlate more highly in male than female individuals | Homo sapiens | - |
| additional information | UGT1A3 expression is always significantly correlated with other UGT1A isoforms in all adults aged below 18 years. In individuals aged above 12 years, expression of UGT1A1/1A4, UGT1A1/1A6,UGT1A1/1A9,and UGT1A4/1A6 significantly correlates, which is not observed in children aged below 12 years. In contrast, UGT1A4/2B7 show significant correlation in children aged below 12 years,but not in individuals aged above 12 years,and this is observed in female but not male individuals. UGT1A3 and UGT1A1 correlate more highly in male than female individuals | Homo sapiens | - |
| additional information | UGT1A3 expression is always significantly correlated with other UGT1A isoforms in all adults aged below 18 years. In individuals aged above 12 years, expression of UGT1A1/1A4, UGT1A1/1A6,UGT1A1/1A9,and UGT1A4/1A6 significantly correlates, which is not observed in children aged below 12 years. In contrast, UGT1A4/2B7 show significant correlation in children aged below 12 years,but not in individuals aged above 12 years,and this is observed in female but not male individuals. UGT1A4 and UGT2B7 correlate more highly in male than female individuals | Homo sapiens | - |
| additional information | UGT1A3 expression is always significantly correlated with other UGT1A isoforms in all adults aged below 18 years. UGT1A3 and UGT1A1 correlate more highly in male than female individuals | Homo sapiens | - |
| additional information | UGT1A6 levels are significantly higher in children than in adults. UGT1A3 expression is always significantly correlated with other UGT1A isoforms in all adults aged below 18 years. In individuals aged above 12 years, expression of UGT1A1/1A4, UGT1A1/1A6,UGT1A1/1A9,and UGT1A4/1A6 significantly correlates, which is not observed in children aged below 12 years. In contrast, UGT1A4/2B7 show significant correlation in children aged below 12 years,but not in individuals aged above 12 years,and this is observed in female but not male individuals. Expression of UGT1A6 and UGT1A9 correlates in the entire sample population. UGT1A4 and UGT1A6 protein correlate more significantly in female than male individuals | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-glucuronate + acceptor | - |
Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UGT1A1 | - |
Homo sapiens |
| UGT1A3 | - |
Homo sapiens |
| UGT1A4 | - |
Homo sapiens |
| UGT1A6 | - |
Homo sapiens |
| UGT1A9 | - |
Homo sapiens |
| UGT2B7 | - |
Homo sapiens |
| UGT3A1 | - |
Homo sapiens |
| UGT3A2 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the uridine diphosphate glucuronosyltransferases (UGTs) catalyze glucuronidation to facilitate systemic and local clearance of numerous chemicals and drugs | Homo sapiens |
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Release 2023.1 (January 2023)
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