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Literature summary for 2.4.1.17 extracted from
- Identification and characterization of human UDP-glucuronosyltransferases responsible for xanthotoxol glucuronidation (2018), Xenobiotica, 48, 109-116 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| xanthotoxol | substrate inhibition of isoform UGT1A1; substrate inhibition of isoform UGT1A10; substrate inhibition of isoform UGT1A8 | Homo sapiens |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00579 | - |
xanthotoxol | enzyme from liver microsomes, at pH 7.4 and 37°C | Homo sapiens | |
| 0.0125 | - |
xanthotoxol | isoform UGT1A10, at pH 7.4 and 37°C | Homo sapiens | |
| 0.0345 | - |
xanthotoxol | enzyme from intestinal microsomes, at pH 7.4 and 37°C | Homo sapiens | |
| 0.04191 | - |
xanthotoxol | isoform UGT1A6, at pH 7.4 and 37°C | Homo sapiens | |
| 0.2024 | - |
xanthotoxol | isoform UGT1A8, at pH 7.4 and 37°C | Homo sapiens | |
| 0.2586 | - |
xanthotoxol | isoform UGT1A3, at pH 7.4 and 37°C | Homo sapiens | |
| 0.4593 | - |
xanthotoxol | isoform Ugt1a1, at pH 7.4 and 37°C | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P16662 | - |
- |
| Homo sapiens | P19224 | - |
- |
| Homo sapiens | P22309 | - |
- |
| Homo sapiens | P35503 | - |
- |
| Homo sapiens | Q9HAW8 | - |
- |
| Homo sapiens | Q9HAW9 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| small intestine | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| xanthotoxol + UDP-glucuronate | - |
Homo sapiens | UDP + xanthotoxol 8-O-glucuronide | - |
? | |
| xanthotoxol + UDP-glucuronate | isoform UGT1A1 is mainly responsible for xanthotoxol glucuronidation in the human liver | Homo sapiens | UDP + xanthotoxol 8-O-glucuronide | - |
? | |
| xanthotoxol + UDP-glucuronate | isoform UGT1A10 is mainly responsible for xanthotoxol glucuronidation in the human small intestine | Homo sapiens | UDP + xanthotoxol 8-O-glucuronide | - |
? | |
| xanthotoxol + UDP-glucuronate | isoform UGT2B7 is mainly responsible for xanthotoxol glucuronidation in the human liver | Homo sapiens | UDP + xanthotoxol 8-O-glucuronide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UDP-glucuronosyltransferase | - |
Homo sapiens |
| UGT1A1 | isoform | Homo sapiens |
| UGT1A10 | isoform | Homo sapiens |
| UGT1A3 | isoform | Homo sapiens |
| UGT1A6 | isoform | Homo sapiens |
| UGT1A8 | isoform | Homo sapiens |
| UGT2B7 | isoform | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.2639 | - |
xanthotoxol | isoform UGT1A8, at pH 7.4 and 37°C | Homo sapiens | |
| 0.612 | - |
xanthotoxol | isoform UGT1A10, at pH 7.4 and 37°C | Homo sapiens | |
| 1.184 | - |
xanthotoxol | isoform UGT1A1, at pH 7.4 and 37°C | Homo sapiens | |
| 1.8 | - |
xanthotoxol | enzyme from intestinal microsomes, at pH 7.4 and 37°C | Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | isoform UGT1A1 is mainly responsible for xanthotoxol glucuronidation in the human liver | Homo sapiens |
| metabolism | isoform UGT1A10 is mainly responsible for xanthotoxol glucuronidation in the human small intestine | Homo sapiens |
| metabolism | isoform UGT2B7 is mainly responsible for xanthotoxol glucuronidation in the human liver | Homo sapiens |
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