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Literature summary for 2.4.1.17 extracted from

  • Li, F.; Wang, S.; Lu, D.; Wang, Y.; Dong, D.; Wu, B.
    Identification of UDP-glucuronosyltransferases 1A1, 1A3 and 2B15 as the main contributors to glucuronidation of bakuchiol, a natural biologically active compound (2017), Xenobiotica, 47, 369-375 .
    View publication on PubMed
Search for more literature for 2.4.1.17

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0035
-
 bakuchiol isoform UGT2B15, at pH 7.4 and 37°C Homo sapiens
0.00441
-
 bakuchiol isoform Ugt1a1, at pH 7.4 and 37°C Homo sapiens
0.01005
-
 bakuchiol isoform UGT1A3, at pH 7.4 and 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P22309
-
-
Homo sapiens P35503
-
-
Homo sapiens P54855
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-hydroxyrofecoxib + UDP-glucuronate
-
 Homo sapiens UDP + 5-hydroxyrofecoxib beta-D-glucuronide
-
 ?
bakuchiol + UDP-glucuronate bakuchiol is 1-(4-hydroxyphenyl)-3,7-dimethyl-3-vinyl-1,6-octadiene. Isoform UGT1A1 is a main contributor to glucuronidation of bakuchiol Homo sapiens UDP + bakuchiol beta-D-glucuronide
-
 ?
bakuchiol + UDP-glucuronate bakuchiol is 1-(4-hydroxyphenyl)-3,7-dimethyl-3-vinyl-1,6-octadiene. Isoform UGT1A3 is a main contributor to glucuronidation of bakuchiol Homo sapiens UDP + bakuchiol beta-D-glucuronide
-
 ?
bakuchiol + UDP-glucuronate bakuchiol is 1-(4-hydroxyphenyl)-3,7-dimethyl-3-vinyl-1,6-octadiene. Isoform UGT2B15 is a main contributor to glucuronidation of bakuchiol Homo sapiens UDP + bakuchiol beta-D-glucuronide
-
 ?
beta-estradiol + UDP-glucuronate
-
 Homo sapiens UDP + beta-estradiol 3-O-beta-D-glucuronoside
-
 ?
chenodeoxycholic acid + UDP-glucuronate
-
 Homo sapiens UDP + chenodeoxycholic acid 24-beta-D-glucuronoside
-
 ?

Synonyms

Synonyms Comment Organism
UDP-glucuronosyltransferase
-
 Homo sapiens
UGT1A1 isoform Homo sapiens
UGT1A3 isoform Homo sapiens
UGT2B15 isoform Homo sapiens