Any feedback?
Literature summary for 2.4.1.17 extracted from
- Inhibitory effect of sauchinone on UDP-glucuronosyltransferase (UGT) 2B7 activity (2018), Molecules, 23, 366 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-naphthol | - |
Homo sapiens |  |
| chrysin | - |
Homo sapiens | |
| efavirenz | - |
Homo sapiens | |
| lithocholic acid | - |
Homo sapiens | |
| sauchinone | noncompetitive inhibition; noncompetitive inhibition | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P16662 | - |
- |
| Homo sapiens | P19224 | - |
- |
| Homo sapiens | P22309 | - |
- |
| Homo sapiens | P35503 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-estradiol + UDP-glucuronate | substrate for isoform UGT1A1 | Homo sapiens | UDP + beta-estradiol-3-glucuronide | - |
? | |
| chenodeoxycholic acid + UDP-glucuronate | substrate for isoform UGT1A3 | Homo sapiens | UDP + ? | - |
? | |
| serotonin + UDP-glucuronate | substrate for isoform UGT1A6 | Homo sapiens | UDP + serotonin beta-D-glucuronide | - |
? | |
| zidovudine + UDP-glucuronate | substrate for isoform UGT2B7 | Homo sapiens | UDP + zidovudine beta-D-glucuronide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UDP-glucuronosyltransferase | - |
Homo sapiens |
| UGT1A1 | isoform | Homo sapiens |
| UGT1A3 | isoform | Homo sapiens |
| UGT1A6 | isoform | Homo sapiens |
| UGT2B7 | isoform | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000524 | - |
sauchinone | isoform UGT2B7, at pH 7.6 and 37°C | Homo sapiens | |
| 0.00108 | - |
sauchinone | isoform UGT1A6, at pH 7.6 and 37°C | Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000279 | - |
isoform UGT2B7, at pH 7.6 and 37°C | Homo sapiens | sauchinone | |
| 0.000758 | - |
isoform UGT1A6, at pH 7.6 and 37°C | Homo sapiens | sauchinone | |
| 0.00883 | - |
isoform UGT1A1, at pH 7.6 and 37°C | Homo sapiens | sauchinone | |
| 0.0283 | - |
isoform UGT1A1, at pH 7.6 and 37°C | Homo sapiens | chrysin | |
| 0.0352 | - |
isoform UGT1A6, at pH 7.6 and 37°C | Homo sapiens | 1-naphthol | |
| 0.0439 | - |
isoform UGT1A3, at pH 7.6 and 37°C | Homo sapiens | sauchinone | |
| 0.0698 | - |
isoform UGT1A3, at pH 7.6 and 37°C | Homo sapiens | lithocholic acid | |
| 0.0754 | - |
isoform UGT2B7, at pH 7.6 and 37°C | Homo sapiens | efavirenz | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
