Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.17 extracted from

  • Koyama, M.; Shirahata, T.; Hirashima, R.; Kobayashi, Y.; Itoh, T.; Fujiwara, R.
    Inhibition of UDP-glucuronosyltransferase (UGT)-mediated glycyrrhetinic acid 3-O-glucuronidation by polyphenols and triterpenoids (2017), Drug Metab. Pharmacokinet., 32, 218-223 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
alisol B
-
Homo sapiens
alisol B acetate
-
Homo sapiens
catechin
-
Homo sapiens
isoliquiritigenin
-
Homo sapiens
additional information not inhibited by glabridin, liquiritigenin, licochalcone A, isoliquiritin, astragaloside IV, alisol A, ergosterol, ginsenoside Rb1, E-arasone, saikosaponin A, linarin, luteolin, luteolin-7-O-glucoside, perilaldehyde, beta-eudesmol, apigenin 7-O-glucoside, betulinic acid, and oleanolic acid Homo sapiens
protopanaxadiol competitive inhibition Homo sapiens
rosmarinic acid
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 4 mM used in assay conditions Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycyrrhetinic acid + UDP-glucuronate
-
Homo sapiens UDP + glycyrrhetinic acid-3-O-glucuronide
-
?

Synonyms

Synonyms Comment Organism
UDP-glucuronosyltransferase
-
Homo sapiens
UGT
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0359
-
protopanaxadiol at pH 7.4 and 37°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0592
-
at pH 7.4 and 37°C Homo sapiens protopanaxadiol
0.0964
-
at pH 7.4 and 37°C Homo sapiens isoliquiritigenin
0.125
-
at pH 7.4 and 37°C Homo sapiens rosmarinic acid
0.16
-
at pH 7.4 and 37°C Homo sapiens alisol B
0.163
-
at pH 7.4 and 37°C Homo sapiens alisol B acetate
0.164
-
at pH 7.4 and 37°C Homo sapiens catechin