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Literature summary for 2.4.1.17 extracted from

  • Shi, X.; Zhang, G.; Ge, G.; Guo, Z.; Song, Y.; Su, D.; Shan, L.
    In Vitro metabolism of auriculasin and its inhibitory effects on human cytochrome P450 and UDP-glucuronosyltransferase enzymes (2019), Chem. Res. Toxicol., 32, 2125-2134 .
    View publication on PubMed
Search for more literature for 2.4.1.17

Inhibitors

Inhibitors Comment Organism Structure
auriculasin auriculasin inhibits isoforms UGT1A6, UGT1A8, UGT1A10, and UGT2B7 completely at 0.1 mM. Isoforms UGT1A1, UGT1A3, UGT1A7, UGT1A9, UGT2B4, and UGT2B15 show about 60%, 95%, 90%, 96%, 55% and 42% residual activity at 0.1 mM auriculasin, respectively Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferone + UDP-glucuronate
-
 Homo sapiens UDP + 4-methylumbelliferyl beta-D-glucuronide
-
 ?

Synonyms

Synonyms Comment Organism
UDP-glucuronosyltransferase
-
 Homo sapiens
UGT1A1 isoform Homo sapiens
UGT1A10 isoform Homo sapiens
UGT1A3 isoform Homo sapiens
UGT1A6 isoform Homo sapiens
UGT1A7 isoform Homo sapiens
UGT1A8 isoform Homo sapiens
UGT1A9 isoform Homo sapiens
UGT2B15 isoform Homo sapiens
UGT2B4 isoform Homo sapiens
UGT2B7 isoform Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00501
-
 auriculasin isoform UGT1A8, at pH 7.4 and 37°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00829
-
 isoform UGT1A8, at pH 7.4 and 37°C Homo sapiens auriculasin