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Literature summary for 2.4.1.17 extracted from
- Regioselective glucuronidation of gingerols by human liver microsomes and expressed UDP-glucuronosyltransferase enzymes: reaction kinetics and activity correlation analyses for UGT1A9 and UGT2B7 (2015), J. Pharm. Pharmacol., 67, 583-596.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Michaelis-Menten kinetic profile, overview | Homo sapiens | |
| additional information | - |
additional information | substrate inhibition kinetics profile, overview | Homo sapiens | |
| 0.0132 | - |
8-gingerol | pH 7.4, temperature not specified in the publication, isozyme UGT1A9 | Homo sapiens |  |
| 0.0178 | - |
10-gingerol | pH 7.4, temperature not specified in the publication, isozyme UGT1A9 | Homo sapiens | |
| 0.0211 | - |
8-gingerol | pH 7.4, temperature not specified in the publication, isozyme UGT2B17 | Homo sapiens | |
| 0.0224 | - |
10-gingerol | pH 7.4, temperature not specified in the publication, isozyme UGT2B7 | Homo sapiens | |
| 0.0235 | - |
8-gingerol | pH 7.4, temperature not specified in the publication, isozyme UGT2B7 | Homo sapiens | |
| 0.0253 | - |
6-gingerol | pH 7.4, temperature not specified in the publication, isozyme UGT2B15 | Homo sapiens | |
| 0.0293 | - |
8-gingerol | pH 7.4, temperature not specified in the publication, isozyme UGT1A1 | Homo sapiens | |
| 0.0308 | - |
10-gingerol | pH 7.4, temperature not specified in the publication, isozyme UGT1A1 | Homo sapiens | |
| 0.0313 | - |
10-gingerol | pH 7.4, temperature not specified in the publication, isozyme UGT2B17 | Homo sapiens | |
| 0.0314 | - |
8-gingerol | pH 7.4, temperature not specified in the publication, isozyme UGT1A8 | Homo sapiens | |
| 0.033 | - |
10-gingerol | pH 7.4, temperature not specified in the publication, isozyme UGT1A8 | Homo sapiens | |
| 0.0353 | - |
10-gingerol | pH 7.4, temperature not specified in the publication, isozyme UGT1A8 | Homo sapiens | |
| 0.0488 | - |
6-gingerol | pH 7.4, temperature not specified in the publication, isozyme UGT2B17 | Homo sapiens | |
| 0.0543 | - |
6-gingerol | pH 7.4, temperature not specified in the publication, isozyme UGT1A8 | Homo sapiens | |
| 0.138 | - |
6-gingerol | pH 7.4, temperature not specified in the publication, isozyme UGT1A8 | Homo sapiens | |
| 0.158 | - |
6-gingerol | pH 7.4, temperature not specified in the publication, isozyme UGT1A9 | Homo sapiens | |
| 0.206 | - |
6-gingerol | pH 7.4, temperature not specified in the publication, isozyme UGT1A10 | Homo sapiens | |
| 0.232 | - |
6-gingerol | pH 7.4, temperature not specified in the publication, isozyme UGT1A1 | Homo sapiens | |
| 0.404 | - |
6-gingerol | pH 7.4, temperature not specified in the publication, isozyme UGT2B7 | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. Formation of 5-O-glucuronide is mainly catalysed by UGT1A9 | ? | - |
? | |
| additional information | Homo sapiens | main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A1 generates glucuronides at 4'-OH sites | ? | - |
? | |
| additional information | Homo sapiens | main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A10 generates glucuronides at 4'-OH sites | ? | - |
? | |
| additional information | Homo sapiens | main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A7 generates glucuronides at 4'-OH sites | ? | - |
? | |
| additional information | Homo sapiens | main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A8 generates glucuronides at 4'-OH sites | ? | - |
? | |
| additional information | Homo sapiens | main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B15 generates glucuronides at 4'-OH sites | ? | - |
? | |
| additional information | Homo sapiens | main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B17 generates glucuronides at 4'-OH sites | ? | - |
? | |
| additional information | Homo sapiens | main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B7 is the only isozyme that generates glucuronides at both 4'-OH and 5-OH sites, although a strong position preference is observed with 4'-OH of over 80.2% | ? | - |
? | |
| additional information | Homo sapiens | no activity with gingerols by enzyme UGT1A3 | ? | - |
? | |
| additional information | Homo sapiens | no activity with gingerols by enzyme UGT1A4 | ? | - |
? | |
| additional information | Homo sapiens | no activity with gingerols by enzyme UGT1A6 | ? | - |
? | |
| additional information | Homo sapiens | no activity with gingerols by enzyme UGT2B4 | ? | - |
? | |
| UDP-glucuronate + 10-gingerol | Homo sapiens | - |
UDP + 10-gingerol 4'-O-beta-D-glucuronoside | - |
? | |
| UDP-glucuronate + 10-gingerol | Homo sapiens | - |
UDP + 10-gingerol 5-O-beta-D-glucuronoside | - |
? | |
| UDP-glucuronate + 6-gingerol | Homo sapiens | - |
UDP + 6-gingerol 4'-O-beta-D-glucuronoside | - |
? | |
| UDP-glucuronate + 6-gingerol | Homo sapiens | - |
UDP + 6-gingerol 5-O-beta-D-glucuronoside | - |
? | |
| UDP-glucuronate + 8-gingerol | Homo sapiens | - |
UDP + 8-gingerol 5-O-beta-D-glucuronoside | - |
? | |
| UDP-glucuronate + 8-gingerol | Homo sapiens | - |
UDP + 8-gingerol 4'-O-beta-D-glucuronoside | - |
? | |
| UDP-glucuronate + gingerol | Homo sapiens | - |
UDP + gingerol 4'-O-beta-D-glucuronoside | - |
? | |
| UDP-glucuronate + propofol | Homo sapiens | - |
UDP + propofol beta-D-glucuronoside | - |
? | |
| UDP-glucuronate + zidovudine | Homo sapiens | - |
UDP + zidovudine beta-D-glucuronoside | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O60656 | - |
- |
| Homo sapiens | O75795 | - |
- |
| Homo sapiens | P06133 | - |
- |
| Homo sapiens | P16662 | - |
- |
| Homo sapiens | P19224 | - |
- |
| Homo sapiens | P22309 | - |
- |
| Homo sapiens | P22310 | - |
- |
| Homo sapiens | P35503 | - |
- |
| Homo sapiens | P54855 | - |
- |
| Homo sapiens | Q9HAW7 | - |
- |
| Homo sapiens | Q9HAW8 | - |
- |
| Homo sapiens | Q9HAW9 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. Formation of 5-O-glucuronide is mainly catalysed by UGT1A9 | Homo sapiens | ? | - |
? | |
| additional information | main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A1 generates glucuronides at 4'-OH sites | Homo sapiens | ? | - |
? | |
| additional information | main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A10 generates glucuronides at 4'-OH sites | Homo sapiens | ? | - |
? | |
| additional information | main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A7 generates glucuronides at 4'-OH sites | Homo sapiens | ? | - |
? | |
| additional information | main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A8 generates glucuronides at 4'-OH sites | Homo sapiens | ? | - |
? | |
| additional information | main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B15 generates glucuronides at 4'-OH sites | Homo sapiens | ? | - |
? | |
| additional information | main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B17 generates glucuronides at 4'-OH sites | Homo sapiens | ? | - |
? | |
| additional information | main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B7 is the only isozyme that generates glucuronides at both 4'-OH and 5-OH sites, although a strong position preference is observed with 4'-OH of over 80.2% | Homo sapiens | ? | - |
? | |
| additional information | no activity with gingerols by enzyme UGT1A3 | Homo sapiens | ? | - |
? | |
| additional information | no activity with gingerols by enzyme UGT1A4 | Homo sapiens | ? | - |
? | |
| additional information | no activity with gingerols by enzyme UGT1A6 | Homo sapiens | ? | - |
? | |
| additional information | no activity with gingerols by enzyme UGT2B4 | Homo sapiens | ? | - |
? | |
| additional information | no activity by isozyme UGT2B15 with 8-gingerol and 10-gingerol | Homo sapiens | ? | - |
? | |
| additional information | no activity with 8-gingerol | Homo sapiens | ? | - |
? | |
| additional information | no activity with 8-gingerol and 10-gingerol | Homo sapiens | ? | - |
? | |
| UDP-glucuronate + 10-gingerol | - |
Homo sapiens | UDP + 10-gingerol 4'-O-beta-D-glucuronoside | - |
? | |
| UDP-glucuronate + 10-gingerol | - |
Homo sapiens | UDP + 10-gingerol 5-O-beta-D-glucuronoside | - |
? | |
| UDP-glucuronate + 6-gingerol | - |
Homo sapiens | UDP + 6-gingerol 4'-O-beta-D-glucuronoside | - |
? | |
| UDP-glucuronate + 6-gingerol | - |
Homo sapiens | UDP + 6-gingerol 5-O-beta-D-glucuronoside | - |
? | |
| UDP-glucuronate + 8-gingerol | - |
Homo sapiens | UDP + 8-gingerol 5-O-beta-D-glucuronoside | - |
? | |
| UDP-glucuronate + 8-gingerol | - |
Homo sapiens | UDP + 8-gingerol 4'-O-beta-D-glucuronoside | - |
? | |
| UDP-glucuronate + gingerol | - |
Homo sapiens | UDP + gingerol 4'-O-beta-D-glucuronoside | - |
? | |
| UDP-glucuronate + propofol | - |
Homo sapiens | UDP + propofol beta-D-glucuronoside | - |
? | |
| UDP-glucuronate + zidovudine | - |
Homo sapiens | UDP + zidovudine beta-D-glucuronoside | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UDP-glucuronosyltransferase | - |
Homo sapiens |
| UGT | - |
Homo sapiens |
| UGT1A1 | - |
Homo sapiens |
| UGT1A10 | - |
Homo sapiens |
| UGT1A3 | - |
Homo sapiens |
| UGT1A4 | - |
Homo sapiens |
| UGT1A6 | - |
Homo sapiens |
| UGT1A7 | - |
Homo sapiens |
| UGT1A8 | - |
Homo sapiens |
| UGT1A9 | - |
Homo sapiens |
| UGT2B15 | - |
Homo sapiens |
| UGT2B17 | - |
Homo sapiens |
| UGT2B4 | - |
Homo sapiens |
| UGT2B7 | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | UGT1A9 and 2B7 are the main contributors to regioselective glucuronidation of gingerols in the liver, isozyme UGT12B7 is primarily responsible for 4'-O-glucuronidation of gingerols in the liver | Homo sapiens |
| physiological function | UGT1A9 and 2B7 are the main contributors to regioselective glucuronidation of gingerols in the liver, isozyme UGT1A9 is primarily responsible for 5-O-glucuronidation of gingerols in the liver | Homo sapiens |
| physiological function | UGT1A9 and 2B7 are the main contributors to regioselective glucuronidation of gingerols in the liver, isozyme UGT2B7 is primarily responsible for 4'-O-glucuronidation of gingerols in the liver | Homo sapiens |
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