Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
17beta-estradiol | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0143 | - |
17beta-estradiol | isoform UGT1A10, pH 7.4, 37°C | Homo sapiens | |
0.0297 | - |
17beta-estradiol | isoform UGT2B7, pH 7.4, 37°C | Homo sapiens | |
0.0975 | - |
17beta-estradiol | isoform UGT2A1, pH 7.4, 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17alpha-estradiol + UDP-alpha-D-glucuronate | - |
Homo sapiens | ? + UDP | - |
? | |
17beta-estradiol + UDP-alpha-D-glucuronate | - |
Homo sapiens | ? + UDP | - |
? | |
additional information | the pattern of human UDP-glucuronosyltransferases of subfamily 2B that glucuronidate ent-17beta-estradiol, particularly 2B15 and 2B17, resembles the glucuronidation of 17alpha-estradiol rather than 17beta-estradiol. The UDP-glucuronosyltransferases of subfamilies 1A and 2A exhibit higher degree of regioselectivity than enantioselectivity in the conjugation of these estradiols, regardless of whether the activity is primarily toward the non-chiral site, 3-OH, or the 17-OH group | Homo sapiens | ? | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.533 | - |
17beta-estradiol | isoform UGT2B7, pH 7.4, 37°C | Homo sapiens | |
1.547 | - |
17beta-estradiol | isoform UGT1A10, pH 7.4, 37°C | Homo sapiens |