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Literature summary for 2.4.1.17 extracted from

  • Mazur, A.; Lichti, C.F.; Prather, P.L.; Zielinska, A.K.; Bratton, S.M.; Gallus-Zawada, A.; Finel, M.; Miller, G.P.; Radominska-Pandya, A.; Moran, J.H.
    Characterization of human hepatic and extrahepatic UDP-glucuronosyltransferase enzymes involved in the metabolism of classic cannabinoids (2009), Drug Metab. Dispos., 37, 1496-1504.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in baculovirus-infected insect cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0034
-
cannabinol isoform UGT1A9, pH 7.4, 37°C Homo sapiens
0.0073
-
(+-)-11-hydroxy-DELTA9-tetrahydrocannabinol isoform UGT1A9, pH 7.4, 37°C Homo sapiens
0.019
-
cannabinol isoform UGT1A7, pH 7.4, 37°C Homo sapiens
0.044
-
cannabinol isoform UGT1A8, pH 7.4, 37°C Homo sapiens
0.059
-
cannabinol isoform UGT1A10, pH 7.4, 37°C Homo sapiens
0.068
-
(-)-11-nor-9-carboxy-DELTA9-tetrahydrocannabinol isoform UGT1A3, pH 7.4, 37°C Homo sapiens
0.072
-
(+-)-11-hydroxy-DELTA9-tetrahydrocannabinol isoform UGT1A10, pH 7.4, 37°C Homo sapiens
0.17
-
(-)-11-nor-9-carboxy-DELTA9-tetrahydrocannabinol isoform UGT1A1, pH 7.4, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(+-)-11-hydroxy-DELTA9-tetrahydrocannabinol + UDP-glucuronate substrate for isoforms UGT1A9 and UGT1A10 Homo sapiens ? + UDP
-
?
(-)-11-nor-9-carboxy-DELTA9-tetrahydrocannabinol + UDP-glucuronate substrate for isoforms UGT1A1 and UGT1A3, no substrate for UGT1A9 and UGT1A10 Homo sapiens ? + UDP
-
?
cannabinol + UDP-glucuronate substrate for hepatic isoform UGT1A9 and extrahepatic UGT1A7, UGT1A8, and UGT1A10 Homo sapiens ? + UDP
-
?