Inhibitors | Comment | Organism | Structure |
---|---|---|---|
androsterone | inhibits protocatechuic aldehyde glucuronidation by isozyme UGT1A9 and slightly by liver microsomes | Homo sapiens | |
Phenylbutazone | inhibits protocatechuic aldehyde glucuronidation by isozyme UGT1A6 and liver microsomes | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics analysis using ecombinant isozymes UGT1A6 and UGT1A9, and liver and intestine microsomes, overview | Homo sapiens | |
0.211 | - |
Protocatechuic aldehyde | pH 7.5, 37°C, recombinant isozyme UGT1A6, formation of product M2 | Homo sapiens | |
0.2385 | - |
Protocatechuic aldehyde | pH 7.5, 37°C, recombinant isozyme UGT1A9, formation of product M2 | Homo sapiens | |
0.337 | - |
Protocatechuic aldehyde | pH 7.5, 37°C, liver microsomes, formation of product M2 | Homo sapiens | |
0.3675 | - |
Protocatechuic aldehyde | pH 7.5, 37°C, recombinant isozyme UGT1A6, formation of product M1 | Homo sapiens | |
0.38 | - |
Protocatechuic aldehyde | pH 7.5, 37°C, recombinant isozyme UGT1A9, formation of product M1 | Homo sapiens | |
0.433 | - |
Protocatechuic aldehyde | pH 7.5, 37°C, liver microsomes, formation of product M1 | Homo sapiens | |
0.494 | - |
Protocatechuic aldehyde | pH 7.5, 37°C, intestine microsomes, formation of product M2 | Homo sapiens | |
0.627 | - |
Protocatechuic aldehyde | pH 7.5, 37°C, intestine microsomes, formation of product M1 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-D-glucuronate + acceptor | Homo sapiens | - |
UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + protocatechuic aldehyde | Homo sapiens | - |
UDP + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P19224 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-D-glucuronate + acceptor | - |
Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + protocatechuic aldehyde | - |
Homo sapiens | UDP + ? | - |
? | |
UDP-D-glucuronate + protocatechuic aldehyde | i.e. 3,4-dihydroxybenzaldehyde, the reaction is catalyzed by recombinant isozyme UGT1A6, especially, and also by isozyme UGT1A9, as well as by liver and intestine microsomes, overview | Homo sapiens | UDP + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase 1A6 | - |
Homo sapiens |
UGT1A6 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0271 | - |
pH 7.5, 37°C, recombinant isozyme UGT1A9 | Homo sapiens | androsterone | |
0.0455 | - |
pH 7.5, 37°C, recombinant isozyme UGT1A6 | Homo sapiens | Phenylbutazone | |
0.0619 | - |
pH 7.5, 37°C, liver microsomes | Homo sapiens | Phenylbutazone |