Literature summary for 2.4.1.17 extracted from

Bowalgaha, K.; Elliot, D.J.; Mackenzie, P.I.; Knights, K.M.; Miners, J.O.
The glucuronidation of DELTA4-3-keto C19- and C21-hydroxysteroids by human liver microsomal and recombinant UDP-glucuronosyltransferases (UGTs): 6alpha- and 21-hydroxyprogesterone are selective substrates for UGT2B7 (2007), Drug Metab. Dispos., 35, 363-370.

Search for more literature for 2.4.1.17

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.003	-	6alpha-hydroxyprogesterone	37°C, pH 7.4	Homo sapiens
0.0038	-	testosterone	37°C, pH 7.4	Homo sapiens
0.0057	-	testosterone	37°C, pH 7.4	Homo sapiens
0.0069	-	11alpha-hydroxyprogesterone	37°C, pH 7.4	Homo sapiens
0.019	-	Mn2+[side2]	37°C, pH 7.4	Homo sapiens
0.055	-	6alpha-hydroxyprogesterone	37°C, pH 7.4	Homo sapiens
0.073	-	16alpha-hydroxyprogesterone	37°C, pH 7.4	Homo sapiens
0.093	-	11alpha-hydroxyprogesterone	37°C, pH 7.4	Homo sapiens
0.211	-	16alpha-hydroxyprogesterone	37°C, pH 7.4	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Homo sapiens	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
11alpha-hydroxyprogesterone + UDP-glucuronate	Homo sapiens	-	UDP + 11alpha-hydroxyprogesterone-11-O-D-glucuronate	-	?
16alpha-hydroxyprogesterone + UDP-glucuronate	Homo sapiens	UGT2B15 and UGT2B17 are the major enzyme forms involved in the high-affinity component of 16alpha-hydroxyprogesterone glucuronidation	?	-	?
16alpha-hydroxyprogesterone + UDP-glucuronate	Homo sapiens	-	UDP + 16alpha-hydroxyprgesterone-16-O-D-glucuronate	-	?
16alpha-hydroxyprogesterone + UDP-glucuronate	Homo sapiens	UGT2B15 and UGT2B17 are the major enzyme forms involved in the high-affinity component of 16alpha-hydroxyprogesterone glucuronidation	UDP + 16alpha-hydroxyprgesterone-16-O-D-glucuronate	-	?
21-hydroxyprogesterone + UDP-glucuronate	Homo sapiens	-	UDP + 21-hydroxyprogesterone-21-O-D-glucuronate	-	?
6alpha-hydroxyprogesterone + UDP-glucuronate	Homo sapiens	-	UDP + 6alpha-hydroxyprogesteron-6-O-alpha-D-glucuronate	-	?
testosterone + UDP-glucuronate	Homo sapiens	UGT2B15 and UGT2B17 are the major enzyme forms involved in human liver microsomal testosterone 17beta-glucuronidation	UDP + testosterone beta-D-glucuronoside	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O60656	-	-
Homo sapiens	O75795	-	-
Homo sapiens	P16662	-	-
Homo sapiens	P22310	-	-
Homo sapiens	P54855	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
11alpha-hydroxyprogesterone + UDP-glucuronate	-	Homo sapiens	UDP + 11alpha-hydroxyprogesterone-11-O-D-glucuronate	-	?
16alpha-hydroxyprogesterone + UDP-glucuronate	-	Homo sapiens	?	-	?
16alpha-hydroxyprogesterone + UDP-glucuronate	UGT2B15 and UGT2B17 are the major enzyme forms involved in the high-affinity component of 16alpha-hydroxyprogesterone glucuronidation	Homo sapiens	?	-	?
16alpha-hydroxyprogesterone + UDP-glucuronate	-	Homo sapiens	UDP + 16alpha-hydroxyprgesterone-16-O-D-glucuronate	-	?
16alpha-hydroxyprogesterone + UDP-glucuronate	UGT2B15 and UGT2B17 are the major enzyme forms involved in the high-affinity component of 16alpha-hydroxyprogesterone glucuronidation	Homo sapiens	UDP + 16alpha-hydroxyprgesterone-16-O-D-glucuronate	-	?
21-hydroxyprogesterone + UDP-glucuronate	-	Homo sapiens	UDP + 21-hydroxyprogesterone-21-O-D-glucuronate	-	?
6alpha-hydroxyprogesterone + UDP-glucuronate	-	Homo sapiens	UDP + 6alpha-hydroxyprogesteron-6-O-alpha-D-glucuronate	-	?
testosterone + UDP-glucuronate	-	Homo sapiens	UDP + testosterone beta-D-glucuronoside	-	?
testosterone + UDP-glucuronate	UGT2B15 and UGT2B17 are the major enzyme forms involved in human liver microsomal testosterone 17beta-glucuronidation	Homo sapiens	UDP + testosterone beta-D-glucuronoside	-	?

Synonyms

Synonyms	Comment	Organism
UGT1A4	-	Homo sapiens
UGT1A9	-	Homo sapiens
UGT2B15	-	Homo sapiens
UGT2B17	-	Homo sapiens
UGT2B7	-	Homo sapiens

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Release 2023.1 (January 2023)