Literature summary for 2.4.1.17 extracted from

Dellinger, R.W.; Fang, J.L.; Chen, G.; Weinberg, R.; Lazarus, P.
Importance of UDP-glucuronosyltransferase 1A10 (UGT1A10) in the detoxification of polycyclic aromatic hydrocarbons: decreased glucuronidative activity of the UGT1A10139Lys isoform (2006), Drug Metab. Dispos., 34, 943-949.

Application

Application	Comment	Organism
medicine	UGT1A10 codon 139 polymorphism may be an important determinant in risk for tobacco-related cancers	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens
stable HEK293 cell lines overexpressing either the UGT1A10139Glu or UGT1A10139Lys isoforms are created	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
E139K	the nonconservative amino change of Glu to Lys at codon 139 renders UGT1A10 less active	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism
0.0097	-	3-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.0098	-	7-hydroxy benzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.0113	-	1-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.0299	-	1-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.0301	-	9-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.0342	-	1-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.0382	-	9-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.0501	-	7-hydroxy benzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.0556	-	3-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.0621	-	7-hydroxy benzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.0633	-	9-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.0635	-	3-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.087	-	1-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.0918	-	9-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.0963	-	1-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.115	-	3-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.125	-	9-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.127	-	7-hydroxy benzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.129	-	7-hydroxy benzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.169	-	1-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.19	-	7-hydroxy benzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.208	-	9-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.209	-	9-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.234	-	3-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.281	-	7-hydroxy benzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.295	-	3-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.348	-	3-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.481	-	9-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.497	-	3-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.542	-	7-hydroxy benzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.583	-	3-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.615	-	9-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
0.854	-	1-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
1.526	-	1-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens
1.588	-	7-hydroxy benzo(a)pyrene	37°C, pH 7.5	Homo sapiens
2.869	-	1-hydroxybenzo(a)pyrene	37°C, pH 7.5	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
UDP-glucuronate + acceptor	Homo sapiens	UGT1A10 is an important detoxifier of polycyclic aromatic hydrocarbons	UDP + acceptor beta-D-glucuronoside	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O60656	recombinant	-
Homo sapiens	O75795	recombinant	-
Homo sapiens	P16662	recombinant	-
Homo sapiens	P22309	recombinant	-
Homo sapiens	P35503	recombinant	-
Homo sapiens	P54855	recombinant	-
Homo sapiens	Q9HAW7	recombinant	-
Homo sapiens	Q9HAW8	-	-
Homo sapiens	Q9HAW9	recombinant	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lung	-	Homo sapiens	-
oral squamous cell carcinoma cell line	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
1-hydroxybenzo(a)pyrene + UDP-glucuronate	-	Homo sapiens	?	-	?
1-hydroxybenzo(a)pyrene + UDP-glucuronate	UGT1A10 exhibited considerably more glucuronidation activity than any other glucuronosyltransferase UGT1A family member	Homo sapiens	?	-	?
1-naphthol + UDP-glucuronate	-	Homo sapiens	1-naphthyl-O-glucuronide + UDP	-	?
3-hydroxybenzo(a)pyrene + UDP-glucuronate	-	Homo sapiens	?	-	?
3-hydroxybenzo(a)pyrene + UDP-glucuronate	UGT1A10 exhibited considerably more glucuronidation activity than any other glucuronosyltransferase UGT1A family member	Homo sapiens	?	-	?
4-methylumbelliferone + UDP-glucuronate	-	Homo sapiens	UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide	-	?
4-nitrophenol + UDP-glucuronate	-	Homo sapiens	4-nitrophenyl beta-D-glucuronide + UDP	-	?
7-hydroxy benzo(a)pyrene + UDP-glucuronate	-	Homo sapiens	?	-	?
7-hydroxy benzo(a)pyrene + UDP-glucuronate	UGT1A10 exhibited considerably more glucuronidation activity than any other glucuronosyltransferase UGT1A family member	Homo sapiens	?	-	?
9-hydroxybenzo(a)pyrene + UDP-glucuronate	-	Homo sapiens	?	-	?
9-hydroxybenzo(a)pyrene + UDP-glucuronate	UGT1A10 exhibited considerably more glucuronidation activity than any other glucuronosyltransferase UGT1A family member	Homo sapiens	?	-	?
UDP-glucuronate + acceptor	UGT1A10 is an important detoxifier of polycyclic aromatic hydrocarbons	Homo sapiens	UDP + acceptor beta-D-glucuronoside	-	?

Synonyms

Synonyms	Comment	Organism
UDP-glucuronosyltransferase 1A1	-	Homo sapiens
UDP-glucuronosyltransferase 1A10	-	Homo sapiens
UDP-glucuronosyltransferase 1A3	-	Homo sapiens
UDP-glucuronosyltransferase 1A7	-	Homo sapiens
UDP-glucuronosyltransferase 1A8	-	Homo sapiens
UDP-glucuronosyltransferase 1A9	-	Homo sapiens
UDP-glucuronosyltransferase 2B15	-	Homo sapiens
UDP-glucuronosyltransferase 2B17	-	Homo sapiens
UDP-glucuronosyltransferase 2B7	-	Homo sapiens
UGT1A1	-	Homo sapiens
UGT1A10	-	Homo sapiens
UGT1A3	-	Homo sapiens
UGT1A7	-	Homo sapiens
UGT1A8	-	Homo sapiens
UGT1A9	-	Homo sapiens
UGT2B15	-	Homo sapiens
UGT2B17	-	Homo sapiens
UGT2B7	-	Homo sapiens