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Literature summary for 2.4.1.17 extracted from

  • Soars, M.G.; Ring, B.J.; Wrighton, S.A.
    The effect of incubation conditions on the enzyme kinetics of UDP-glucuronosyltransferases (2003), Drug Metab. Dispos., 31, 762-767.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
alamethicin
-
Homo sapiens
Brij58
-
Homo sapiens
additional information sonication activates Homo sapiens
phosphate activity in phosphate buffer is higher than in Tris/malate buffer containing 5 mM sucrose Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics, at different conditions with different activators and different substrates, microsomes or recombinant isozymes, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozymes UGT1A1, UGT1A6, UGT1A9, UGT2B7, and UGT2B15
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
activity at different conditions with different activators and different substrates, microsomes or recombinant isozymes, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information substrate specificities of different isozymes Homo sapiens ?
-
?
UDP-glucuronate + 3,17-estradiol isozyme UGT1A1 Homo sapiens UDP + 17-estradiol 3-O-glucuronide
-
?
UDP-glucuronate + 3,17-estradiol isozyme UGT1A1 Homo sapiens UDP + 3-estradiol 17-O-glucuronide
-
?
UDP-glucuronate + androstane-3,17-diol isozyme UGT2B15 Homo sapiens UDP + androstane-3,17-diol 17-O-beta-D-glucuronide
-
?
UDP-glucuronate + anthraflavic acid isozyme UGT1A1 Homo sapiens UDP + anthraflavic acid 2-glucuronide
-
?
UDP-glucuronate + buprenorphine isozyme UGT1A1 Homo sapiens UDP + buprenorphine glucuronide
-
?
UDP-glucuronate + ethinylestradiol isozyme UGT1A1 Homo sapiens UDP + ethinylestradiol glucuronide
-
?
UDP-glucuronate + morphine isozyme UGT1A1 Homo sapiens UDP + morphine-3-beta-D-glucuronide
-
?
UDP-glucuronate + morphine isozyme UGT1A1 Homo sapiens UDP + morphine-6-beta-D-glucuronide
-
?
UDP-glucuronate + naphthol isozyme UGT1A6 Homo sapiens UDP + naphthol glucuronide
-
?
UDP-glucuronate + propofol isozyme UGT1A9 Homo sapiens UDP + propofol beta-D-glucuronide
-
?

Synonyms

Synonyms Comment Organism
UDP-glucuronosyltransferase
-
Homo sapiens
UGT
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.1 7.4 assay at Homo sapiens