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Literature summary for 2.4.1.17 extracted from
- Expression and Characterization of Recombinant Human UDP-glucuronosyltransferases (UGTs) (2003), J. Biol. Chem., 278, 3536-3544.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Phospholipids | - |
Homo sapiens |  |
| Triton X-100 | stimulates UGT1A9 activity | Homo sapiens | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| 8 different UGT's expressed in baculovirus-infected cells as His-tagged proteins | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Triton X-100 | inhibition of UGT2B and almost all of the UGT1A isozymes, not inhibit glucuronidation of 1-naphthol nor scopoletin by UGT1A9, inhibition of entacapone glucuronidation tested on isozymes of UGT1A and UGT1B families, only for UGT1A9 showed reversible inhibition | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.061 | - |
scopoletin | apparent Km for membrane-bound UGT1AB | Homo sapiens | |
| 0.229 | - |
UDP-glucuronic acid | apparent Km for membrane-bound UGT1AB | Homo sapiens | |
| 0.704 | - |
UDP-glucuronic acid | apparent Km for purified UGT1AB | Homo sapiens | |
| 0.79 | - |
scopoletin | apparent Km for purified UGT1AB | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| microsome | - |
Homo sapiens | - |
- |
| nuclear membrane | - |
Homo sapiens | 31965 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| His-tagged UGT1A9 purified by immobilized metal-chelating chromatography | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-naphthol + UDP-glucuronate | - |
Homo sapiens | naphth-1-yl-beta-D-glucuronide + UDP | - |
? | |
| scopoletin + UDPglucuronate | - |
Homo sapiens | UDP + scopoletin O-glucuronide | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | suggested homodimer | Homo sapiens |
| ? | all values determined by SDS-PAGE | Homo sapiens |
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