Any feedback?
Literature summary for 2.4.1.17 extracted from
- Isolation and characterization of a UDP-glucuronosyltransferase (UGT1A01) cloned from female rhesus monkey (2002), Arch. Biochem. Biophys., 402, 289-295.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| rhesus UGT1A1 expressed in HK-293 cells | Macaca mulatta |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.028 | - |
ethinylestradiol | apparent Km for microsomal preparation | Macaca mulatta |  |
| 0.035 | - |
beta estradiol | apparent Km for microsomal preparation | Macaca mulatta | |
| 0.04 | - |
bilirubin | apparent Km for microsomal preparation | Macaca mulatta | |
| 0.044 | - |
7-hydroxy-4-(trifluoromethyl)-coumarin | apparent Km for microsomal preparation | Macaca mulatta | |
| 0.33 | - |
1-naphthol | apparent Km for microsomal preparation | Macaca mulatta | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 55000 | - |
UGT1A01 | Macaca mulatta |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Macaca mulatta | - |
rhesus monkey | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Macaca mulatta | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-naphthol + UDP-glucuronate | - |
Macaca mulatta | naphth-1-yl-beta-D-glucuronide + UDP | - |
? | |
| 17alpha-ethynylestradiol + UDP-glucuronate | - |
Macaca mulatta | UDP + 17alpha-ethynylestradiol 3-O-beta-D-glucuronide | - |
? | |
| 7-hydroxy-4-(trifluoromethyl)-coumarin + UDPglucuronate | - |
Macaca mulatta | UDP + 7-hydroxy-4-(trifluoromethyl)-coumarin O-glucuronide | - |
? | |
| beta-estradiol + UDPglucuronate | - |
Macaca mulatta | beta-estradiol-3-glucuronide + UDP | - |
? | |
| bilirubin + UDPglucuronate | - |
Macaca mulatta | bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP | - |
? | |
| ethinylestradiol + UDPglucuronate | - |
Macaca mulatta | UDP + ethinylestradiol-3-glucuronide | - |
? | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
